Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expr...

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Detalles Bibliográficos
Autores principales: Kanazawa, Yuji, Nagano, Mamoru, Koinuma, Satoshi, Sugiyo, Shinichi, Shigeyoshi, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340794/
https://www.ncbi.nlm.nih.gov/pubmed/35349694
http://dx.doi.org/10.1093/jmicro/dfac016
Descripción
Sumario:We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.

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