Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expr...

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Detalles Bibliográficos
Autores principales: Kanazawa, Yuji, Nagano, Mamoru, Koinuma, Satoshi, Sugiyo, Shinichi, Shigeyoshi, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340794/
https://www.ncbi.nlm.nih.gov/pubmed/35349694
http://dx.doi.org/10.1093/jmicro/dfac016
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author Kanazawa, Yuji
Nagano, Mamoru
Koinuma, Satoshi
Sugiyo, Shinichi
Shigeyoshi, Yasufumi
author_facet Kanazawa, Yuji
Nagano, Mamoru
Koinuma, Satoshi
Sugiyo, Shinichi
Shigeyoshi, Yasufumi
author_sort Kanazawa, Yuji
collection PubMed
description We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.
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spelling pubmed-93407942022-08-01 Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats Kanazawa, Yuji Nagano, Mamoru Koinuma, Satoshi Sugiyo, Shinichi Shigeyoshi, Yasufumi Microscopy (Oxf) Letter We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors. Oxford University Press 2022-03-29 /pmc/articles/PMC9340794/ /pubmed/35349694 http://dx.doi.org/10.1093/jmicro/dfac016 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Society of Microscopy. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Letter
Kanazawa, Yuji
Nagano, Mamoru
Koinuma, Satoshi
Sugiyo, Shinichi
Shigeyoshi, Yasufumi
Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
title Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
title_full Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
title_fullStr Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
title_full_unstemmed Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
title_short Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
title_sort effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340794/
https://www.ncbi.nlm.nih.gov/pubmed/35349694
http://dx.doi.org/10.1093/jmicro/dfac016
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