Cargando…
Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study
AIMS/INTRODUCTION: The cardiometabolic index (CMI) has been proposed as a novel indicator of cardiometabolic status. This study aimed to investigate the effects of CMI and its longitudinal transitions on the development of type 2 diabetes mellitus in middle‐aged and older Chinese. MATERIALS AND METH...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340876/ https://www.ncbi.nlm.nih.gov/pubmed/35426487 http://dx.doi.org/10.1111/jdi.13805 |
_version_ | 1784760490900062208 |
---|---|
author | Qiu, Yiwen Yi, Qian Li, Shuting Sun, Weidi Ren, Ziyang Shen, Yaojia Wu, Yuhang Wang, Zhicheng Xia, Wei Song, Peige |
author_facet | Qiu, Yiwen Yi, Qian Li, Shuting Sun, Weidi Ren, Ziyang Shen, Yaojia Wu, Yuhang Wang, Zhicheng Xia, Wei Song, Peige |
author_sort | Qiu, Yiwen |
collection | PubMed |
description | AIMS/INTRODUCTION: The cardiometabolic index (CMI) has been proposed as a novel indicator of cardiometabolic status. This study aimed to investigate the effects of CMI and its longitudinal transitions on the development of type 2 diabetes mellitus in middle‐aged and older Chinese. MATERIALS AND METHODS: We used data from the China Health and Retirement Longitudinal Study (2011–2018). CMI was calculated as the product of the waist circumference to height ratio and the triglyceride to high‐density lipoprotein cholesterol ratio. At baseline in 2011, the subjects were classified into low‐ and high‐CMI groups, and then divided into four transition patterns during follow‐up, i.e. maintained‐low, low‐to‐high, high‐to‐low, and maintained‐high CMI. The hazard ratios (HRs) of different transition patterns for type 2 diabetes mellitus were calculated using multivariable Cox frailty models. RESULTS: During 2011–2018, 7,347 participants were included. Participants with a high‐CMI at baseline had a significantly higher risk of new‐onset type 2 diabetes mellitus than those with a low‐CMI (HR = 1.78, 95% CI:1.55–2.05). For subjects with a low‐CMI at baseline, the risk of developing type 2 diabetes mellitus increased by 75% if their CMI status changed to high during follow‐up (HR(low‐to‐high) = 1.75, 95% CI:1.35–2.28). Meanwhile, for subjects with a maintained‐high CMI, no significant risk reduction for type 2 diabetes mellitus was found when their CMI changed to low status (HR(high‐to‐low) = 0.77, 95% CI: 0.58–1.01). CONCLUSIONS: Baseline CMI levels and longitudinal CMI transition patterns were associated with a higher risk of type 2 diabetes mellitus. Early anti‐lipid measures should be taken to prevent type 2 diabetes mellitus in middle‐aged and older Chinese. |
format | Online Article Text |
id | pubmed-9340876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93408762022-08-02 Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study Qiu, Yiwen Yi, Qian Li, Shuting Sun, Weidi Ren, Ziyang Shen, Yaojia Wu, Yuhang Wang, Zhicheng Xia, Wei Song, Peige J Diabetes Investig Articles AIMS/INTRODUCTION: The cardiometabolic index (CMI) has been proposed as a novel indicator of cardiometabolic status. This study aimed to investigate the effects of CMI and its longitudinal transitions on the development of type 2 diabetes mellitus in middle‐aged and older Chinese. MATERIALS AND METHODS: We used data from the China Health and Retirement Longitudinal Study (2011–2018). CMI was calculated as the product of the waist circumference to height ratio and the triglyceride to high‐density lipoprotein cholesterol ratio. At baseline in 2011, the subjects were classified into low‐ and high‐CMI groups, and then divided into four transition patterns during follow‐up, i.e. maintained‐low, low‐to‐high, high‐to‐low, and maintained‐high CMI. The hazard ratios (HRs) of different transition patterns for type 2 diabetes mellitus were calculated using multivariable Cox frailty models. RESULTS: During 2011–2018, 7,347 participants were included. Participants with a high‐CMI at baseline had a significantly higher risk of new‐onset type 2 diabetes mellitus than those with a low‐CMI (HR = 1.78, 95% CI:1.55–2.05). For subjects with a low‐CMI at baseline, the risk of developing type 2 diabetes mellitus increased by 75% if their CMI status changed to high during follow‐up (HR(low‐to‐high) = 1.75, 95% CI:1.35–2.28). Meanwhile, for subjects with a maintained‐high CMI, no significant risk reduction for type 2 diabetes mellitus was found when their CMI changed to low status (HR(high‐to‐low) = 0.77, 95% CI: 0.58–1.01). CONCLUSIONS: Baseline CMI levels and longitudinal CMI transition patterns were associated with a higher risk of type 2 diabetes mellitus. Early anti‐lipid measures should be taken to prevent type 2 diabetes mellitus in middle‐aged and older Chinese. John Wiley and Sons Inc. 2022-05-05 2022-08 /pmc/articles/PMC9340876/ /pubmed/35426487 http://dx.doi.org/10.1111/jdi.13805 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Qiu, Yiwen Yi, Qian Li, Shuting Sun, Weidi Ren, Ziyang Shen, Yaojia Wu, Yuhang Wang, Zhicheng Xia, Wei Song, Peige Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study |
title | Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study |
title_full | Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study |
title_fullStr | Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study |
title_full_unstemmed | Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study |
title_short | Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older Chinese: A national cohort study |
title_sort | transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle‐aged and older chinese: a national cohort study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340876/ https://www.ncbi.nlm.nih.gov/pubmed/35426487 http://dx.doi.org/10.1111/jdi.13805 |
work_keys_str_mv | AT qiuyiwen transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT yiqian transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT lishuting transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT sunweidi transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT renziyang transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT shenyaojia transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT wuyuhang transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT wangzhicheng transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT xiawei transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy AT songpeige transitionofcardiometabolicstatusandtheriskoftype2diabetesmellitusamongmiddleagedandolderchineseanationalcohortstudy |