Restrictive fluid therapy and high-dose vitamin C in sepsis

Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might...

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Detalles Bibliográficos
Autores principales: Plummer, Mark Philip, Bellomo, Rinaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341155/
https://www.ncbi.nlm.nih.gov/pubmed/35915241
http://dx.doi.org/10.1038/s41581-022-00609-5
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author Plummer, Mark Philip
Bellomo, Rinaldo
author_facet Plummer, Mark Philip
Bellomo, Rinaldo
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description Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis.
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spelling pubmed-93411552022-08-01 Restrictive fluid therapy and high-dose vitamin C in sepsis Plummer, Mark Philip Bellomo, Rinaldo Nat Rev Nephrol News & Views Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis. Nature Publishing Group UK 2022-08-01 2022 /pmc/articles/PMC9341155/ /pubmed/35915241 http://dx.doi.org/10.1038/s41581-022-00609-5 Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle News & Views
Plummer, Mark Philip
Bellomo, Rinaldo
Restrictive fluid therapy and high-dose vitamin C in sepsis
title Restrictive fluid therapy and high-dose vitamin C in sepsis
title_full Restrictive fluid therapy and high-dose vitamin C in sepsis
title_fullStr Restrictive fluid therapy and high-dose vitamin C in sepsis
title_full_unstemmed Restrictive fluid therapy and high-dose vitamin C in sepsis
title_short Restrictive fluid therapy and high-dose vitamin C in sepsis
title_sort restrictive fluid therapy and high-dose vitamin c in sepsis
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341155/
https://www.ncbi.nlm.nih.gov/pubmed/35915241
http://dx.doi.org/10.1038/s41581-022-00609-5
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