Dynamics of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes

Broad domains of H3K4 methylation have been associated with consistent expression of tissue-specific, cell identity, and tumor suppressor genes. Here, we identified broad domain–associated genes in healthy human thymic T cell populations and a collection of T cell acute lymphoblastic leukemia (T-ALL...

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Detalles Bibliográficos
Autores principales: Belhocine, Mohamed, Simonin, Mathieu, Abad Flores, José David, Cieslak, Agata, Manosalva, Iris, Pradel, Lydie, Smith, Charlotte, Mathieu, Eve-Lyne, Charbonnier, Guillaume, Martens, Joost H.A., Stunnenberg, Hendrik G., Maqbool, Muhammad Ahmad, Mikulasova, Aneta, Russell, Lisa J., Rico, Daniel, Puthier, Denis, Ferrier, Pierre, Asnafi, Vahid, Spicuglia, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341507/
https://www.ncbi.nlm.nih.gov/pubmed/34162697
http://dx.doi.org/10.1101/gr.266924.120

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