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The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

BACKGROUND & AIMS: Few epidemiological studies have investigated the relationships of urinary essential and non-essential elements with serum albumin, an indicator of nutritional status, especially for the elderly in China. METHODS: A community-based study among elderly participants (n = 275) wa...

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Autores principales: Li, Ang, Zhou, Quan, Mei, Yayuan, Zhao, Jiaxin, Liu, Liu, Zhao, Meiduo, Xu, Jing, Ge, Xiaoyu, Xu, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342688/
https://www.ncbi.nlm.nih.gov/pubmed/35923200
http://dx.doi.org/10.3389/fnut.2022.946245
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author Li, Ang
Zhou, Quan
Mei, Yayuan
Zhao, Jiaxin
Liu, Liu
Zhao, Meiduo
Xu, Jing
Ge, Xiaoyu
Xu, Qun
author_facet Li, Ang
Zhou, Quan
Mei, Yayuan
Zhao, Jiaxin
Liu, Liu
Zhao, Meiduo
Xu, Jing
Ge, Xiaoyu
Xu, Qun
author_sort Li, Ang
collection PubMed
description BACKGROUND & AIMS: Few epidemiological studies have investigated the relationships of urinary essential and non-essential elements with serum albumin, an indicator of nutritional status, especially for the elderly in China. METHODS: A community-based study among elderly participants (n = 275) was conducted in Beijing from November to December 2016. We measured 15 urinary elements concentrations and serum albumin levels. Three statistical methods including the generalized linear model (GLM), quantile g-computation model (qgcomp) and bayesian kernel machine regression (BKMR) were adapted. RESULTS: In GLM analysis, we observed decreased serum albumin levels associated with elevated urinary concentrations of aluminum, arsenic, barium, cobalt, chromium, copper, iron, manganese, selenium, strontium, and zinc. Compared with the lowest tertile, the highest tertile of cadmium and cesium was also negatively associated with serum albumin. Urinary selenium concentration had the most significant negative contribution (30.05%) in the qgcomp analysis. The negative correlations of element mixtures with serum albumin were also observed in BKMR analysis. CONCLUSIONS: Our findings suggested the negative associations of essential and non-essential elements with serum albumin among the elderly. Large-scare cohort studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms.
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spelling pubmed-93426882022-08-02 The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing Li, Ang Zhou, Quan Mei, Yayuan Zhao, Jiaxin Liu, Liu Zhao, Meiduo Xu, Jing Ge, Xiaoyu Xu, Qun Front Nutr Nutrition BACKGROUND & AIMS: Few epidemiological studies have investigated the relationships of urinary essential and non-essential elements with serum albumin, an indicator of nutritional status, especially for the elderly in China. METHODS: A community-based study among elderly participants (n = 275) was conducted in Beijing from November to December 2016. We measured 15 urinary elements concentrations and serum albumin levels. Three statistical methods including the generalized linear model (GLM), quantile g-computation model (qgcomp) and bayesian kernel machine regression (BKMR) were adapted. RESULTS: In GLM analysis, we observed decreased serum albumin levels associated with elevated urinary concentrations of aluminum, arsenic, barium, cobalt, chromium, copper, iron, manganese, selenium, strontium, and zinc. Compared with the lowest tertile, the highest tertile of cadmium and cesium was also negatively associated with serum albumin. Urinary selenium concentration had the most significant negative contribution (30.05%) in the qgcomp analysis. The negative correlations of element mixtures with serum albumin were also observed in BKMR analysis. CONCLUSIONS: Our findings suggested the negative associations of essential and non-essential elements with serum albumin among the elderly. Large-scare cohort studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms. Frontiers Media S.A. 2022-07-18 /pmc/articles/PMC9342688/ /pubmed/35923200 http://dx.doi.org/10.3389/fnut.2022.946245 Text en Copyright © 2022 Li, Zhou, Mei, Zhao, Liu, Zhao, Xu, Ge and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Li, Ang
Zhou, Quan
Mei, Yayuan
Zhao, Jiaxin
Liu, Liu
Zhao, Meiduo
Xu, Jing
Ge, Xiaoyu
Xu, Qun
The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing
title The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing
title_full The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing
title_fullStr The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing
title_full_unstemmed The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing
title_short The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing
title_sort effect of urinary essential and non-essential elements on serum albumin: evidence from a community-based study of the elderly in beijing
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342688/
https://www.ncbi.nlm.nih.gov/pubmed/35923200
http://dx.doi.org/10.3389/fnut.2022.946245
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