A Tissue-Tended Mycophenolate-Modified Nanoparticle Alleviates Systemic Lupus Erythematosus in MRL/Lpr Mouse Model Mainly by Promoting Local M2-Like Macrophagocytes Polarization

BACKGROUND: Mycophenolate mofetil (MMF), for which the bioactive metabolite is mycophenolic acid (MPA), is a frequently used immunosuppressant for systemic lupus erythematosus (SLE). However, its short half-life and poor biodistribution into cells and tissues hinder its clinical efficacy. Our dextra...

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Detalles Bibliográficos
Autores principales: Jiang, Biling, Zhang, Yamin, Li, Yuce, Chen, Yu, Sha, Shanshan, Zhao, Liang, Li, Danqi, Wen, Jingjing, Lan, Jiajia, Lou, Yuchen, Su, Hua, Zhang, Chun, Zhu, Jintao, Tao, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342721/
https://www.ncbi.nlm.nih.gov/pubmed/35924257
http://dx.doi.org/10.2147/IJN.S361400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342721/
https://www.ncbi.nlm.nih.gov/pubmed/35924257
http://dx.doi.org/10.2147/IJN.S361400

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