Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models

Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6. In vitro studies have suggested these mutations affect several signaling pathwa...

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Detalles Bibliográficos
Autores principales: Brown, Brittney J., Boekell, Kimber L., Stotter, Brian R., Talbot, Brianna E., Schlondorff, Johannes S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342776/
https://www.ncbi.nlm.nih.gov/pubmed/35913909
http://dx.doi.org/10.1371/journal.pone.0272313

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