Multi-color dSTORM microscopy in Hormad1(-/)(-) spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure

Recombinases RAD51 and its meiosis-specific paralog DMC1 accumulate on single-stranded DNA (ssDNA) of programmed DNA double strand breaks (DSBs) in meiosis. Here we used three-color dSTORM microscopy, and a mouse model with severe defects in meiotic DSB formation and synapsis (Hormad1(-/-)) to obtai...

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Detalles Bibliográficos
Autores principales: Koornneef, Lieke, Slotman, Johan A., Sleddens-Linkels, Esther, van Cappellen, Wiggert A., Barchi, Marco, Tóth, Attila, Gribnau, Joost, Houtsmuller, Adriaan B., Baarends, Willy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342782/
https://www.ncbi.nlm.nih.gov/pubmed/35857787
http://dx.doi.org/10.1371/journal.pgen.1010046

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