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PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

The protein kinase PKN2 is required for embryonic development and PKN2 knockout mice die as a result of failure in the expansion of mesoderm, cardiac development and neural tube closure. In the adult, cardiomyocyte PKN2 and PKN1 (in combination) are required for cardiac adaptation to pressure-overlo...

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Detalles Bibliográficos
Autores principales:	Marshall, Jacqueline J.T., Cull, Joshua J., Alharbi, Hajed O., Zaw Thin, May, Cooper, Susanna T.E., Barrington, Christopher, Vanyai, Hannah, Snoeks, Thomas, Siow, Bernard, Suáarez-Bonnet, Alejandro, Herbert, Eleanor, Stuckey, Daniel J., Cameron, Angus J.M., Prin, Fabrice, Cook, Andrew C., Priestnall, Simon L., Chotani, Sonia, Rackham, Owen J. L., Meijles, Daniel N., Mohun, Tim, Clerk, Angela, Parker, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Cardiovascular System & Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342899/ https://www.ncbi.nlm.nih.gov/pubmed/35730579 http://dx.doi.org/10.1042/BCJ20220281

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