Cholesterol Binds the Amphipathic Helix of IFITM3 and Regulates Antiviral Activity

The interferon-induced transmembrane (IFITM) proteins broadly inhibit the entry of diverse pathogenic viruses, including Influenza A virus (IAV), Zika virus, HIV-1, and SARS coronaviruses by inhibiting virus-cell membrane fusion. IFITM3 was previously shown to disrupt cholesterol trafficking, but th...

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Detalles Bibliográficos
Autores principales: Rahman, Kazi, Datta, Siddhartha A.K., Beaven, Andrew H., Jolley, Abigail A., Sodt, Alexander J., Compton, Alex A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342930/
https://www.ncbi.nlm.nih.gov/pubmed/35872070
http://dx.doi.org/10.1016/j.jmb.2022.167759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342930/
https://www.ncbi.nlm.nih.gov/pubmed/35872070
http://dx.doi.org/10.1016/j.jmb.2022.167759

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