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The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT
BACKGROUND AND AIM: Anal squamous cell carcinoma (SCC) and oropharyngeal cancer (OPC) are rare tumors associated with HPV infection. Bioumoral predictors of response to chemoradiation (CT-RT) are lacking in these settings. With the aim to find new biomarkers, we investigated the role of eosinophils...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342937/ https://www.ncbi.nlm.nih.gov/pubmed/35915202 http://dx.doi.org/10.1007/s12029-022-00850-y |
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author | Rimini, Margherita Franco, Pierfrancesco Bertolini, Federica Berardino, De Bari giulia, Zampino Maria Stefano, Vegge Andrikou, Kalliopi Arcadipane, Francesca Napolitano, Martina Buno, Lavajo Vieira Alessandra, Gerardi Marianna Olivero, Francesco Ferreri, Filippo Ricardi, Umberto Cascinu, Stefano Casadei-Gardini, Andrea |
author_facet | Rimini, Margherita Franco, Pierfrancesco Bertolini, Federica Berardino, De Bari giulia, Zampino Maria Stefano, Vegge Andrikou, Kalliopi Arcadipane, Francesca Napolitano, Martina Buno, Lavajo Vieira Alessandra, Gerardi Marianna Olivero, Francesco Ferreri, Filippo Ricardi, Umberto Cascinu, Stefano Casadei-Gardini, Andrea |
author_sort | Rimini, Margherita |
collection | PubMed |
description | BACKGROUND AND AIM: Anal squamous cell carcinoma (SCC) and oropharyngeal cancer (OPC) are rare tumors associated with HPV infection. Bioumoral predictors of response to chemoradiation (CT-RT) are lacking in these settings. With the aim to find new biomarkers, we investigated the role of eosinophils in both HPV-positive anal SCC and HPV-related oropharyngeal cancer (OPC). METHODS: We retrieved clinical and laboratory data of patients with HPV-positive anal SCC treated with CT-RT in 5 institutions, and patients with locally advanced OPC SCC treated with CT-RT in 2 institutions. We examined the association between baseline eosinophil count (the best cutoff has been evaluated by ROC curve analysis: 100 × 10^9/L) and disease-free survival (DFS). Unadjusted and adjusted hazard ratios by baseline characteristics were calculated using the Cox proportional hazards model. RESULTS: Three hundred four patients with HPV-positive anal SCCs and 168 patients with OPCs (122 HPV-positive, 46 HPV-negative diseases) were analyzed. In anal SCC, low eosinophil count (< 100 × 10^9/L) correlates to a better DFS (HR = 0.59; p = 0.0392); likewise, in HPV-positive OPC, low eosinophil count correlates to a better DFS (HR = 0.50; p = 0.0428). In HPV-negative OPC, low eosinophil count confers worse DFS compared to high eosinophil count (HR = 3.53; p = 0.0098). After adjustment for age and sex, eosinophils were confirmed to be independent prognostic factors for DFS (HR = 4.55; p = 0.0139). CONCLUSION: Eosinophil count could be used as a prognostic factor in anal HPV-positive SCC. The worse prognosis showed in HPV-positive patients with high eosinophil count is likely to derive from an unfavorable interaction between the HPV-induced immunomodulation and eosinophils, which may hamper the curative effect of RT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12029-022-00850-y. |
format | Online Article Text |
id | pubmed-9342937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-93429372022-08-02 The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT Rimini, Margherita Franco, Pierfrancesco Bertolini, Federica Berardino, De Bari giulia, Zampino Maria Stefano, Vegge Andrikou, Kalliopi Arcadipane, Francesca Napolitano, Martina Buno, Lavajo Vieira Alessandra, Gerardi Marianna Olivero, Francesco Ferreri, Filippo Ricardi, Umberto Cascinu, Stefano Casadei-Gardini, Andrea J Gastrointest Cancer Original Research BACKGROUND AND AIM: Anal squamous cell carcinoma (SCC) and oropharyngeal cancer (OPC) are rare tumors associated with HPV infection. Bioumoral predictors of response to chemoradiation (CT-RT) are lacking in these settings. With the aim to find new biomarkers, we investigated the role of eosinophils in both HPV-positive anal SCC and HPV-related oropharyngeal cancer (OPC). METHODS: We retrieved clinical and laboratory data of patients with HPV-positive anal SCC treated with CT-RT in 5 institutions, and patients with locally advanced OPC SCC treated with CT-RT in 2 institutions. We examined the association between baseline eosinophil count (the best cutoff has been evaluated by ROC curve analysis: 100 × 10^9/L) and disease-free survival (DFS). Unadjusted and adjusted hazard ratios by baseline characteristics were calculated using the Cox proportional hazards model. RESULTS: Three hundred four patients with HPV-positive anal SCCs and 168 patients with OPCs (122 HPV-positive, 46 HPV-negative diseases) were analyzed. In anal SCC, low eosinophil count (< 100 × 10^9/L) correlates to a better DFS (HR = 0.59; p = 0.0392); likewise, in HPV-positive OPC, low eosinophil count correlates to a better DFS (HR = 0.50; p = 0.0428). In HPV-negative OPC, low eosinophil count confers worse DFS compared to high eosinophil count (HR = 3.53; p = 0.0098). After adjustment for age and sex, eosinophils were confirmed to be independent prognostic factors for DFS (HR = 4.55; p = 0.0139). CONCLUSION: Eosinophil count could be used as a prognostic factor in anal HPV-positive SCC. The worse prognosis showed in HPV-positive patients with high eosinophil count is likely to derive from an unfavorable interaction between the HPV-induced immunomodulation and eosinophils, which may hamper the curative effect of RT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12029-022-00850-y. Springer US 2022-08-01 2023 /pmc/articles/PMC9342937/ /pubmed/35915202 http://dx.doi.org/10.1007/s12029-022-00850-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Rimini, Margherita Franco, Pierfrancesco Bertolini, Federica Berardino, De Bari giulia, Zampino Maria Stefano, Vegge Andrikou, Kalliopi Arcadipane, Francesca Napolitano, Martina Buno, Lavajo Vieira Alessandra, Gerardi Marianna Olivero, Francesco Ferreri, Filippo Ricardi, Umberto Cascinu, Stefano Casadei-Gardini, Andrea The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT |
title | The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT |
title_full | The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT |
title_fullStr | The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT |
title_full_unstemmed | The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT |
title_short | The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT |
title_sort | prognostic role of baseline eosinophils in hpv-related cancers: a multi-institutional analysis of anal scc and opc patients treated with radical ct-rt |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342937/ https://www.ncbi.nlm.nih.gov/pubmed/35915202 http://dx.doi.org/10.1007/s12029-022-00850-y |
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