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Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors

Immunometabolic reprogramming due to adenosine produced by CD73 (encoded by the 5’-ectonucleotidase gene NT5E) is a recognized immunosuppressive mechanism contributing to immune evasion in solid tumors. Adenosine is not only known to contribute to tumor progression, but it has specific roles in driv...

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Detalles Bibliográficos
Autores principales:	Chambers, Andrea M, Lupo, Kyle B, Wang, Jiao, Cao, Jingming, Utturkar, Sagar, Lanman, Nadia, Bernal-Crespo, Victor, Jalal, Shadia, Pine, Sharon R, Torregrosa-Allen, Sandra, Elzey, Bennett D, Matosevic, Sandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342955/ https://www.ncbi.nlm.nih.gov/pubmed/35815945 http://dx.doi.org/10.7554/eLife.73699

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