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Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

Mitochondria play a central role in metabolic homeostasis, and dysfunction of this organelle underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with alternating cationic and aromatic residues such as SS-31 (elamipretide) show promise as therapeutic compounds for mitoc...

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Detalles Bibliográficos
Autores principales:	Mitchell, Wayne, Tamucci, Jeffrey D, Ng, Emery L, Liu, Shaoyi, Birk, Alexander V, Szeto, Hazel H, May, Eric R, Alexandrescu, Andrei T, Alder, Nathan N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342957/ https://www.ncbi.nlm.nih.gov/pubmed/35913044 http://dx.doi.org/10.7554/eLife.75531

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