A nucleation barrier spring-loads the CBM signalosome for binary activation

Immune cells activate in binary, switch-like fashion via large protein assemblies known as signalosomes, but the molecular mechanism of the switch is not yet understood. Here, we employed an in-cell biophysical approach to dissect the assembly mechanism of the CARD-BCL10-MALT1 (CBM) signalosome, whi...

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Detalles Bibliográficos
Autores principales: Rodriguez Gama, Alejandro, Miller, Tayla, Lange, Jeffrey J, Unruh, Jay R, Halfmann, Randal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342958/
https://www.ncbi.nlm.nih.gov/pubmed/35727133
http://dx.doi.org/10.7554/eLife.79826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342958/
https://www.ncbi.nlm.nih.gov/pubmed/35727133
http://dx.doi.org/10.7554/eLife.79826

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