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Reward enhances connectivity between the ventral striatum and the default mode network

The default mode network (DMN) has been theorized to participate in a range of social, cognitive, and affective functions. Yet, previous accounts do not consider how the DMN contributes to other brain regions depending on psychological context, thus rendering our understanding of DMN function incomp...

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Detalles Bibliográficos
Autores principales: Dobryakova, Ekaterina, Smith, David V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343171/
https://www.ncbi.nlm.nih.gov/pubmed/35724856
http://dx.doi.org/10.1016/j.neuroimage.2022.119398
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author Dobryakova, Ekaterina
Smith, David V.
author_facet Dobryakova, Ekaterina
Smith, David V.
author_sort Dobryakova, Ekaterina
collection PubMed
description The default mode network (DMN) has been theorized to participate in a range of social, cognitive, and affective functions. Yet, previous accounts do not consider how the DMN contributes to other brain regions depending on psychological context, thus rendering our understanding of DMN function incomplete. We addressed this gap by applying a novel network-based psychophysiological interaction (nPPI) analysis to the reward task within the Human Connectome Project. We first focused on the task-evoked responses of the DMN and other networks involving the prefrontal cortex, including the executive control network (salience network) and the left and right frontoparietal networks. Consistent with a host of prior studies, the DMN exhibited a relative decrease in activation during the task, while the other networks exhibited a relative increase during the task. Next, we used nPPI analyses to assess whether these networks exhibit task-dependent changes in connectivity with other brain regions. Strikingly, we found that the experience of reward enhances task-dependent connectivity between the DMN and the ventral striatum, an effect that was specific to the DMN. Surprisingly, the strength of DMN-VS connectivity was correlated with personality characteristics relating to openness. Taken together, these results advance models of DMN by demonstrating how it contributes to other brain systems during task performance and how those contributions relate to individual differences.
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spelling pubmed-93431712022-09-01 Reward enhances connectivity between the ventral striatum and the default mode network Dobryakova, Ekaterina Smith, David V. Neuroimage Article The default mode network (DMN) has been theorized to participate in a range of social, cognitive, and affective functions. Yet, previous accounts do not consider how the DMN contributes to other brain regions depending on psychological context, thus rendering our understanding of DMN function incomplete. We addressed this gap by applying a novel network-based psychophysiological interaction (nPPI) analysis to the reward task within the Human Connectome Project. We first focused on the task-evoked responses of the DMN and other networks involving the prefrontal cortex, including the executive control network (salience network) and the left and right frontoparietal networks. Consistent with a host of prior studies, the DMN exhibited a relative decrease in activation during the task, while the other networks exhibited a relative increase during the task. Next, we used nPPI analyses to assess whether these networks exhibit task-dependent changes in connectivity with other brain regions. Strikingly, we found that the experience of reward enhances task-dependent connectivity between the DMN and the ventral striatum, an effect that was specific to the DMN. Surprisingly, the strength of DMN-VS connectivity was correlated with personality characteristics relating to openness. Taken together, these results advance models of DMN by demonstrating how it contributes to other brain systems during task performance and how those contributions relate to individual differences. 2022-09 2022-06-18 /pmc/articles/PMC9343171/ /pubmed/35724856 http://dx.doi.org/10.1016/j.neuroimage.2022.119398 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Dobryakova, Ekaterina
Smith, David V.
Reward enhances connectivity between the ventral striatum and the default mode network
title Reward enhances connectivity between the ventral striatum and the default mode network
title_full Reward enhances connectivity between the ventral striatum and the default mode network
title_fullStr Reward enhances connectivity between the ventral striatum and the default mode network
title_full_unstemmed Reward enhances connectivity between the ventral striatum and the default mode network
title_short Reward enhances connectivity between the ventral striatum and the default mode network
title_sort reward enhances connectivity between the ventral striatum and the default mode network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343171/
https://www.ncbi.nlm.nih.gov/pubmed/35724856
http://dx.doi.org/10.1016/j.neuroimage.2022.119398
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