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Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood

To advance understanding of the heterogeneity in the course of ADHD, joint symptom trajectories of inattention and hyperactivity-impulsivity from childhood to young adulthood were modelled and associated with genetic, demographic, and clinical characteristics. Data were obtained from the NeuroIMAGE...

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Autores principales: Vos, Melissa, Rommelse, Nanda N. J., Franke, Barbara, Oosterlaan, Jaap, Heslenfeld, Dirk J., Hoekstra, Pieter J., Klein, Marieke, Faraone, Stephen V., Buitelaar, Jan K., Hartman, Catharina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343304/
https://www.ncbi.nlm.nih.gov/pubmed/33813662
http://dx.doi.org/10.1007/s00787-021-01764-z
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author Vos, Melissa
Rommelse, Nanda N. J.
Franke, Barbara
Oosterlaan, Jaap
Heslenfeld, Dirk J.
Hoekstra, Pieter J.
Klein, Marieke
Faraone, Stephen V.
Buitelaar, Jan K.
Hartman, Catharina A.
author_facet Vos, Melissa
Rommelse, Nanda N. J.
Franke, Barbara
Oosterlaan, Jaap
Heslenfeld, Dirk J.
Hoekstra, Pieter J.
Klein, Marieke
Faraone, Stephen V.
Buitelaar, Jan K.
Hartman, Catharina A.
author_sort Vos, Melissa
collection PubMed
description To advance understanding of the heterogeneity in the course of ADHD, joint symptom trajectories of inattention and hyperactivity-impulsivity from childhood to young adulthood were modelled and associated with genetic, demographic, and clinical characteristics. Data were obtained from the NeuroIMAGE cohort which includes 485 individuals with ADHD, their 665 siblings, and 399 typically developing children. Trajectories were based on scores of the Conners Parent Rating Scale Revised and estimated over seven homogeneous age bins (from 5 to 28 years) using parallel process latent class growth analysis on data collected across 2–4 time points. Multilevel multinomial logistic regression was used to identify characteristics that differentiated between the derived classes. A seven-class solution revealed “severe combined stable” (4.8%), “severe combined decreasing” (13%), “severe inattentive stable” (4.8%), “moderate combined increasing” (7.5%), “moderate combined decreasing” (12.7%), “stable mild” (12.9%), and “stable low” (44.3%) classes. Polygenic risk for depression, ADHD diagnosis, ADHD medication use, IQ, comorbid symptom levels (foremost oppositional behaviour), and functional impairment levels differentiated classes with similar ADHD symptom levels in childhood but a diverging course thereafter. The course of ADHD is highly heterogeneous, with stable, decreasing, and increasing trajectories. Overall, severe symptom levels in childhood are associated with elevated-to-severe symptom levels in adolescence and young adulthood, despite substantial symptom reductions. Beyond symptom severity in childhood, genetic, demographic, and clinical characteristics distinguish the heterogeneous course. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00787-021-01764-z.
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spelling pubmed-93433042022-08-03 Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood Vos, Melissa Rommelse, Nanda N. J. Franke, Barbara Oosterlaan, Jaap Heslenfeld, Dirk J. Hoekstra, Pieter J. Klein, Marieke Faraone, Stephen V. Buitelaar, Jan K. Hartman, Catharina A. Eur Child Adolesc Psychiatry Original Contribution To advance understanding of the heterogeneity in the course of ADHD, joint symptom trajectories of inattention and hyperactivity-impulsivity from childhood to young adulthood were modelled and associated with genetic, demographic, and clinical characteristics. Data were obtained from the NeuroIMAGE cohort which includes 485 individuals with ADHD, their 665 siblings, and 399 typically developing children. Trajectories were based on scores of the Conners Parent Rating Scale Revised and estimated over seven homogeneous age bins (from 5 to 28 years) using parallel process latent class growth analysis on data collected across 2–4 time points. Multilevel multinomial logistic regression was used to identify characteristics that differentiated between the derived classes. A seven-class solution revealed “severe combined stable” (4.8%), “severe combined decreasing” (13%), “severe inattentive stable” (4.8%), “moderate combined increasing” (7.5%), “moderate combined decreasing” (12.7%), “stable mild” (12.9%), and “stable low” (44.3%) classes. Polygenic risk for depression, ADHD diagnosis, ADHD medication use, IQ, comorbid symptom levels (foremost oppositional behaviour), and functional impairment levels differentiated classes with similar ADHD symptom levels in childhood but a diverging course thereafter. The course of ADHD is highly heterogeneous, with stable, decreasing, and increasing trajectories. Overall, severe symptom levels in childhood are associated with elevated-to-severe symptom levels in adolescence and young adulthood, despite substantial symptom reductions. Beyond symptom severity in childhood, genetic, demographic, and clinical characteristics distinguish the heterogeneous course. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00787-021-01764-z. Springer Berlin Heidelberg 2021-04-03 2022 /pmc/articles/PMC9343304/ /pubmed/33813662 http://dx.doi.org/10.1007/s00787-021-01764-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
Vos, Melissa
Rommelse, Nanda N. J.
Franke, Barbara
Oosterlaan, Jaap
Heslenfeld, Dirk J.
Hoekstra, Pieter J.
Klein, Marieke
Faraone, Stephen V.
Buitelaar, Jan K.
Hartman, Catharina A.
Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
title Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
title_full Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
title_fullStr Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
title_full_unstemmed Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
title_short Characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
title_sort characterizing the heterogeneous course of inattention and hyperactivity-impulsivity from childhood to young adulthood
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343304/
https://www.ncbi.nlm.nih.gov/pubmed/33813662
http://dx.doi.org/10.1007/s00787-021-01764-z
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