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Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy
The digestion of gluten generates toxic peptides, among which a highly immunogenic proline-rich 33-mer from wheat α-gliadin, that trigger coeliac disease. Neprosin from the pitcher plant is a reported prolyl endopeptidase. Here, we produce recombinant neprosin and its mutants, and find that full-len...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343461/ https://www.ncbi.nlm.nih.gov/pubmed/35915115 http://dx.doi.org/10.1038/s41467-022-32215-1 |