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Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy

The digestion of gluten generates toxic peptides, among which a highly immunogenic proline-rich 33-mer from wheat α-gliadin, that trigger coeliac disease. Neprosin from the pitcher plant is a reported prolyl endopeptidase. Here, we produce recombinant neprosin and its mutants, and find that full-len...

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Detalles Bibliográficos
Autores principales:	del Amo-Maestro, Laura, Mendes, Soraia R., Rodríguez-Banqueri, Arturo, Garzon-Flores, Laura, Girbal, Marina, Rodríguez-Lagunas, María José, Guevara, Tibisay, Franch, Àngels, Pérez-Cano, Francisco J., Eckhard, Ulrich, Gomis-Rüth, F. Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343461/ https://www.ncbi.nlm.nih.gov/pubmed/35915115 http://dx.doi.org/10.1038/s41467-022-32215-1

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