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Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens

Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in which a bacterial cell becomes insensitive to one (or even) more antibiotic(s). However, the molecular basis for these two antibiotic-tolerant phenotypes is fundamentally different. Whereas antibiotic resis...

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Autores principales: Eisenreich, Wolfgang, Rudel, Thomas, Heesemann, Jürgen, Goebel, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343593/
https://www.ncbi.nlm.nih.gov/pubmed/35928205
http://dx.doi.org/10.3389/fcimb.2022.900848
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author Eisenreich, Wolfgang
Rudel, Thomas
Heesemann, Jürgen
Goebel, Werner
author_facet Eisenreich, Wolfgang
Rudel, Thomas
Heesemann, Jürgen
Goebel, Werner
author_sort Eisenreich, Wolfgang
collection PubMed
description Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in which a bacterial cell becomes insensitive to one (or even) more antibiotic(s). However, the molecular basis for these two antibiotic-tolerant phenotypes is fundamentally different. Whereas antibiotic resistance is genetically determined and hence represents a rather stable phenotype, antibiotic persistence marks a transient physiological state triggered by various stress-inducing conditions that switches back to the original antibiotic sensitive state once the environmental situation improves. The molecular basics of antibiotic resistance are in principle well understood. This is not the case for antibiotic persistence. Under all culture conditions, there is a stochastically formed, subpopulation of persister cells in bacterial populations, the size of which depends on the culture conditions. The proportion of persisters in a bacterial population increases under different stress conditions, including treatment with bactericidal antibiotics (BCAs). Various models have been proposed to explain the formation of persistence in bacteria. We recently hypothesized that all physiological culture conditions leading to persistence converge in the inability of the bacteria to re-initiate a new round of DNA replication caused by an insufficient level of the initiator complex ATP-DnaA and hence by the lack of formation of a functional orisome. Here, we extend this hypothesis by proposing that in this persistence state the bacteria become more susceptible to mutation-based antibiotic resistance provided they are equipped with error-prone DNA repair functions. This is - in our opinion - in particular the case when such bacterial populations are exposed to BCAs.
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spelling pubmed-93435932022-08-03 Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens Eisenreich, Wolfgang Rudel, Thomas Heesemann, Jürgen Goebel, Werner Front Cell Infect Microbiol Cellular and Infection Microbiology Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in which a bacterial cell becomes insensitive to one (or even) more antibiotic(s). However, the molecular basis for these two antibiotic-tolerant phenotypes is fundamentally different. Whereas antibiotic resistance is genetically determined and hence represents a rather stable phenotype, antibiotic persistence marks a transient physiological state triggered by various stress-inducing conditions that switches back to the original antibiotic sensitive state once the environmental situation improves. The molecular basics of antibiotic resistance are in principle well understood. This is not the case for antibiotic persistence. Under all culture conditions, there is a stochastically formed, subpopulation of persister cells in bacterial populations, the size of which depends on the culture conditions. The proportion of persisters in a bacterial population increases under different stress conditions, including treatment with bactericidal antibiotics (BCAs). Various models have been proposed to explain the formation of persistence in bacteria. We recently hypothesized that all physiological culture conditions leading to persistence converge in the inability of the bacteria to re-initiate a new round of DNA replication caused by an insufficient level of the initiator complex ATP-DnaA and hence by the lack of formation of a functional orisome. Here, we extend this hypothesis by proposing that in this persistence state the bacteria become more susceptible to mutation-based antibiotic resistance provided they are equipped with error-prone DNA repair functions. This is - in our opinion - in particular the case when such bacterial populations are exposed to BCAs. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9343593/ /pubmed/35928205 http://dx.doi.org/10.3389/fcimb.2022.900848 Text en Copyright © 2022 Eisenreich, Rudel, Heesemann and Goebel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Eisenreich, Wolfgang
Rudel, Thomas
Heesemann, Jürgen
Goebel, Werner
Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens
title Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens
title_full Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens
title_fullStr Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens
title_full_unstemmed Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens
title_short Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens
title_sort link between antibiotic persistence and antibiotic resistance in bacterial pathogens
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343593/
https://www.ncbi.nlm.nih.gov/pubmed/35928205
http://dx.doi.org/10.3389/fcimb.2022.900848
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