Breast cancer cell-derived extracellular vesicles promote CD8(+) T cell exhaustion via TGF-β type II receptor signaling

Cancer immunotherapies have shown clinical success in various types of tumors but the patient response rate is low, particularly in breast cancer. Here we report that malignant breast cancer cells can transfer active TGF-β type II receptor (TβRII) via tumor-derived extracellular vesicles (TEV) and t...

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Detalles Bibliográficos
Autores principales: Xie, Feng, Zhou, Xiaoxue, Su, Peng, Li, Heyu, Tu, Yifei, Du, Jinjin, Pan, Chen, Wei, Xiang, Zheng, Min, Jin, Ke, Miao, Liyan, Wang, Chao, Meng, Xuli, van Dam, Hans, ten Dijke, Peter, Zhang, Long, Zhou, Fangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343611/
https://www.ncbi.nlm.nih.gov/pubmed/35915084
http://dx.doi.org/10.1038/s41467-022-31250-2

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