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The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study

AIM: To determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk. METHODS: 35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at...

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Autores principales: Xu, Min, Qi, Yan, Chen, Gang, Qin, Yingfen, Wu, Shengli, Wang, Tiange, Zhao, Zhiyun, Xu, Yu, Li, Mian, Chen, Li, Chen, Lulu, Chen, Yuhong, Deng, Huacong, Gao, Zhengnan, Huo, Yanan, Li, Qiang, Liu, Chao, Luo, Zuojie, Mu, Yiming, Qin, Guijun, Shen, Feixia, Shi, Lixin, Su, Qing, Wan, Qin, Wang, Guixia, Wang, Shuangyuan, Wang, Youmin, Hu, Ruying, Xu, Yiping, Yan, Li, Yang, Tao, Yu, Xuefeng, Zhang, Yinfei, Zeng, Tianshu, Tang, Xulei, Ye, Zhen, Zhao, Jiajun, Bi, Yufang, Ning, Guang, Lu, Jieli, Wang, Weiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343618/
https://www.ncbi.nlm.nih.gov/pubmed/35928888
http://dx.doi.org/10.3389/fendo.2022.927067
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author Xu, Min
Qi, Yan
Chen, Gang
Qin, Yingfen
Wu, Shengli
Wang, Tiange
Zhao, Zhiyun
Xu, Yu
Li, Mian
Chen, Li
Chen, Lulu
Chen, Yuhong
Deng, Huacong
Gao, Zhengnan
Huo, Yanan
Li, Qiang
Liu, Chao
Luo, Zuojie
Mu, Yiming
Qin, Guijun
Shen, Feixia
Shi, Lixin
Su, Qing
Wan, Qin
Wang, Guixia
Wang, Shuangyuan
Wang, Youmin
Hu, Ruying
Xu, Yiping
Yan, Li
Yang, Tao
Yu, Xuefeng
Zhang, Yinfei
Zeng, Tianshu
Tang, Xulei
Ye, Zhen
Zhao, Jiajun
Bi, Yufang
Ning, Guang
Lu, Jieli
Wang, Weiqing
author_facet Xu, Min
Qi, Yan
Chen, Gang
Qin, Yingfen
Wu, Shengli
Wang, Tiange
Zhao, Zhiyun
Xu, Yu
Li, Mian
Chen, Li
Chen, Lulu
Chen, Yuhong
Deng, Huacong
Gao, Zhengnan
Huo, Yanan
Li, Qiang
Liu, Chao
Luo, Zuojie
Mu, Yiming
Qin, Guijun
Shen, Feixia
Shi, Lixin
Su, Qing
Wan, Qin
Wang, Guixia
Wang, Shuangyuan
Wang, Youmin
Hu, Ruying
Xu, Yiping
Yan, Li
Yang, Tao
Yu, Xuefeng
Zhang, Yinfei
Zeng, Tianshu
Tang, Xulei
Ye, Zhen
Zhao, Jiajun
Bi, Yufang
Ning, Guang
Lu, Jieli
Wang, Weiqing
author_sort Xu, Min
collection PubMed
description AIM: To determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk. METHODS: 35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at baseline were excluded. Body weight at 20, 30, 40, and 50 years was reported. The overall 30 years and each 10-year weight gain were calculated from the early and middle life. Cox regression models were used to estimate risks of incident diabetes. RESULTS: After 127,745.26 person-years of follow-up, 2,789 incident diabetes were identified (incidence rate, 2.18%) in 25,289 women (mean weight gain 20-50 years, 7.60 kg) and 10,322 men (7.93 kg). Each 10-kg weight gain over the 30 years was significantly associated with a 39.7% increased risk of incident diabetes (95% confidence interval [CI], 1.33-1.47); weight gain from 20-30 years showed a more prominent effect on the risk of developing diabetes before 60 years than that of after 60 years (Hazard ratio, HR = 1.084, 95% CI [1.049-1.121], P <0.0001 vs. 1.015 [0.975-1.056], P = 0.4643; P (Interaction)=0.0293). It showed a stable effect of the three 10-year intervals weight gain on risk of diabetes after 60 years (HR=1.055, 1.038, 1.043, respectively, all P < 0.0036). CONCLUSIONS: The early life weight gain showed a more prominent effect on developing diabetes before 60 years than after 60 years; however, each-decade weight gain from 20 to 50 years showed a similar effect on risk developing diabetes after 60 years.
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spelling pubmed-93436182022-08-03 The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study Xu, Min Qi, Yan Chen, Gang Qin, Yingfen Wu, Shengli Wang, Tiange Zhao, Zhiyun Xu, Yu Li, Mian Chen, Li Chen, Lulu Chen, Yuhong Deng, Huacong Gao, Zhengnan Huo, Yanan Li, Qiang Liu, Chao Luo, Zuojie Mu, Yiming Qin, Guijun Shen, Feixia Shi, Lixin Su, Qing Wan, Qin Wang, Guixia Wang, Shuangyuan Wang, Youmin Hu, Ruying Xu, Yiping Yan, Li Yang, Tao Yu, Xuefeng Zhang, Yinfei Zeng, Tianshu Tang, Xulei Ye, Zhen Zhao, Jiajun Bi, Yufang Ning, Guang Lu, Jieli Wang, Weiqing Front Endocrinol (Lausanne) Endocrinology AIM: To determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk. METHODS: 35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at baseline were excluded. Body weight at 20, 30, 40, and 50 years was reported. The overall 30 years and each 10-year weight gain were calculated from the early and middle life. Cox regression models were used to estimate risks of incident diabetes. RESULTS: After 127,745.26 person-years of follow-up, 2,789 incident diabetes were identified (incidence rate, 2.18%) in 25,289 women (mean weight gain 20-50 years, 7.60 kg) and 10,322 men (7.93 kg). Each 10-kg weight gain over the 30 years was significantly associated with a 39.7% increased risk of incident diabetes (95% confidence interval [CI], 1.33-1.47); weight gain from 20-30 years showed a more prominent effect on the risk of developing diabetes before 60 years than that of after 60 years (Hazard ratio, HR = 1.084, 95% CI [1.049-1.121], P <0.0001 vs. 1.015 [0.975-1.056], P = 0.4643; P (Interaction)=0.0293). It showed a stable effect of the three 10-year intervals weight gain on risk of diabetes after 60 years (HR=1.055, 1.038, 1.043, respectively, all P < 0.0036). CONCLUSIONS: The early life weight gain showed a more prominent effect on developing diabetes before 60 years than after 60 years; however, each-decade weight gain from 20 to 50 years showed a similar effect on risk developing diabetes after 60 years. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9343618/ /pubmed/35928888 http://dx.doi.org/10.3389/fendo.2022.927067 Text en Copyright © 2022 Xu, Qi, Chen, Qin, Wu, Wang, Zhao, Xu, Li, Chen, Chen, Chen, Deng, Gao, Huo, Li, Liu, Luo, Mu, Qin, Shen, Shi, Su, Wan, Wang, Wang, Wang, Hu, Xu, Yan, Yang, Yu, Zhang, Zeng, Tang, Ye, Zhao, Bi, Ning, Lu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Xu, Min
Qi, Yan
Chen, Gang
Qin, Yingfen
Wu, Shengli
Wang, Tiange
Zhao, Zhiyun
Xu, Yu
Li, Mian
Chen, Li
Chen, Lulu
Chen, Yuhong
Deng, Huacong
Gao, Zhengnan
Huo, Yanan
Li, Qiang
Liu, Chao
Luo, Zuojie
Mu, Yiming
Qin, Guijun
Shen, Feixia
Shi, Lixin
Su, Qing
Wan, Qin
Wang, Guixia
Wang, Shuangyuan
Wang, Youmin
Hu, Ruying
Xu, Yiping
Yan, Li
Yang, Tao
Yu, Xuefeng
Zhang, Yinfei
Zeng, Tianshu
Tang, Xulei
Ye, Zhen
Zhao, Jiajun
Bi, Yufang
Ning, Guang
Lu, Jieli
Wang, Weiqing
The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
title The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
title_full The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
title_fullStr The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
title_full_unstemmed The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
title_short The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study
title_sort relative body weight gain from early to middle life adulthood associated with later life risk of diabetes: a nationwide cohort study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343618/
https://www.ncbi.nlm.nih.gov/pubmed/35928888
http://dx.doi.org/10.3389/fendo.2022.927067
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