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Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Neosporosis is a worldwide infectious disease caused by intracellular parasite Neospora caninum that is a major pathogen of abortion in cattle and neurological disorders in other hosts. However, limited data are available on animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA), a...

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Autores principales: Qi, Tongsheng, Ai, Jingkai, Yang, Jinfang, Zhu, Heng, Zhou, Yuyu, Zhu, Yulu, Zhang, Heming, Qin, Qi, Kang, Ming, Sun, Yali, Li, Jixu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343756/
https://www.ncbi.nlm.nih.gov/pubmed/35928116
http://dx.doi.org/10.3389/fvets.2022.953380
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author Qi, Tongsheng
Ai, Jingkai
Yang, Jinfang
Zhu, Heng
Zhou, Yuyu
Zhu, Yulu
Zhang, Heming
Qin, Qi
Kang, Ming
Sun, Yali
Li, Jixu
author_facet Qi, Tongsheng
Ai, Jingkai
Yang, Jinfang
Zhu, Heng
Zhou, Yuyu
Zhu, Yulu
Zhang, Heming
Qin, Qi
Kang, Ming
Sun, Yali
Li, Jixu
author_sort Qi, Tongsheng
collection PubMed
description Neosporosis is a worldwide infectious disease caused by intracellular parasite Neospora caninum that is a major pathogen of abortion in cattle and neurological disorders in other hosts. However, limited data are available on animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA), and little is known about whether animals in the plateau area play an important role in the epidemiology of N. caninum. Therefore, indirect ELISAs based on a combination of NcSAG1 and NcGRA7 antigens were developed to examine both N. caninum-specific IgG and IgM antibodies in Tibetan sheep, yak, cow, pig, cattle, horse, chicken, camel, and donkey from the QTPA in this study. The results showed that all current species present- IgG and IgM-positive animals, and that the overall seroprevalence of N. caninum were 18.6 (703/3,782) and 48.1% (1,820/3,782) for the IgG and IgM antibodies, respectively. Further analysis found significant differences from different altitudes in IgG in Tibetan sheep and IgM in the yak. Hence, the present serological results indicate that the tested animal populations in the QTPA are suffering from N. caninum infections or have become carriers of N. caninum antibodies. To the best of our knowledge, this is the first report on current N. caninum-infected animals in the QTPA, the first epidemiology of neosporosis in cow and camel in China, and the first record of N. caninum IgM antibodies in all the surveyed animals in China. This study provides the latest valuable data on the epidemiology of neosporosis in China and in plateau areas of the world.
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spelling pubmed-93437562022-08-03 Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau Qi, Tongsheng Ai, Jingkai Yang, Jinfang Zhu, Heng Zhou, Yuyu Zhu, Yulu Zhang, Heming Qin, Qi Kang, Ming Sun, Yali Li, Jixu Front Vet Sci Veterinary Science Neosporosis is a worldwide infectious disease caused by intracellular parasite Neospora caninum that is a major pathogen of abortion in cattle and neurological disorders in other hosts. However, limited data are available on animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA), and little is known about whether animals in the plateau area play an important role in the epidemiology of N. caninum. Therefore, indirect ELISAs based on a combination of NcSAG1 and NcGRA7 antigens were developed to examine both N. caninum-specific IgG and IgM antibodies in Tibetan sheep, yak, cow, pig, cattle, horse, chicken, camel, and donkey from the QTPA in this study. The results showed that all current species present- IgG and IgM-positive animals, and that the overall seroprevalence of N. caninum were 18.6 (703/3,782) and 48.1% (1,820/3,782) for the IgG and IgM antibodies, respectively. Further analysis found significant differences from different altitudes in IgG in Tibetan sheep and IgM in the yak. Hence, the present serological results indicate that the tested animal populations in the QTPA are suffering from N. caninum infections or have become carriers of N. caninum antibodies. To the best of our knowledge, this is the first report on current N. caninum-infected animals in the QTPA, the first epidemiology of neosporosis in cow and camel in China, and the first record of N. caninum IgM antibodies in all the surveyed animals in China. This study provides the latest valuable data on the epidemiology of neosporosis in China and in plateau areas of the world. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9343756/ /pubmed/35928116 http://dx.doi.org/10.3389/fvets.2022.953380 Text en Copyright © 2022 Qi, Ai, Yang, Zhu, Zhou, Zhu, Zhang, Qin, Kang, Sun and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Qi, Tongsheng
Ai, Jingkai
Yang, Jinfang
Zhu, Heng
Zhou, Yuyu
Zhu, Yulu
Zhang, Heming
Qin, Qi
Kang, Ming
Sun, Yali
Li, Jixu
Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau
title Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau
title_full Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau
title_fullStr Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau
title_full_unstemmed Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau
title_short Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau
title_sort seroepidemiology of neosporosis in various animals in the qinghai-tibetan plateau
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343756/
https://www.ncbi.nlm.nih.gov/pubmed/35928116
http://dx.doi.org/10.3389/fvets.2022.953380
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