Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation

Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond regulating LDL cholesterol (LDL-c) plasma levels, exerts several pleiotropic effects by modulating lipid metabolism in extrahepatic cells such as macrophages. Macrophage cholesterol homeostasis depends on serum lipoprotein functions, incl...

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Detalles Bibliográficos
Autores principales: Palumbo, Marcella, Giammanco, Antonina, Purrello, Francesco, Pavanello, Chiara, Mombelli, Giuliana, Di Pino, Antonino, Piro, Salvatore, Cefalù, Angelo Baldassare, Calabresi, Laura, Averna, Maurizio, Bernini, Franco, Zimetti, Francesca, Adorni, Maria Pia, Scicali, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343790/
https://www.ncbi.nlm.nih.gov/pubmed/35928226
http://dx.doi.org/10.3389/fmolb.2022.925587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343790/
https://www.ncbi.nlm.nih.gov/pubmed/35928226
http://dx.doi.org/10.3389/fmolb.2022.925587

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