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The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression

Accumulated evidence has revealed that F-box protein, a subunit of SCF E3 ubiquitin ligase complexes, participates in carcinogenesis and tumor progression via targeting its substrates for ubiquitination and degradation. F-box proteins could be regulated by cellular signaling pathways and noncoding R...

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Autores principales: Xia, Lu, Chen, Jingyun, Huang, Min, Mei, Jie, Lin, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343830/
https://www.ncbi.nlm.nih.gov/pubmed/35928868
http://dx.doi.org/10.3389/fonc.2022.963617
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author Xia, Lu
Chen, Jingyun
Huang, Min
Mei, Jie
Lin, Min
author_facet Xia, Lu
Chen, Jingyun
Huang, Min
Mei, Jie
Lin, Min
author_sort Xia, Lu
collection PubMed
description Accumulated evidence has revealed that F-box protein, a subunit of SCF E3 ubiquitin ligase complexes, participates in carcinogenesis and tumor progression via targeting its substrates for ubiquitination and degradation. F-box proteins could be regulated by cellular signaling pathways and noncoding RNAs in tumorigenesis. Long noncoding RNA (lncRNA), one type of noncoding RNAs, has been identified to modulate the expression of F-box proteins and contribute to oncogenesis. In this review, we summarize the role and mechanisms of multiple lncRNAs in regulating F-box proteins in tumorigenesis, including lncRNAs SLC7A11-AS1, MT1JP, TUG1, FER1L4, TTN-AS1, CASC2, MALAT1, TINCR, PCGEM1, linc01436, linc00494, GATA6-AS1, and ODIR1. Moreover, we discuss that targeting these lncRNAs could be helpful for treating cancer via modulating F-box protein expression. We hope our review can stimulate the research on exploration of molecular insight into how F-box proteins are governed in carcinogenesis. Therefore, modulation of lncRNAs is a potential therapeutic strategy for cancer therapy via regulation of F-box proteins.
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spelling pubmed-93438302022-08-03 The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression Xia, Lu Chen, Jingyun Huang, Min Mei, Jie Lin, Min Front Oncol Oncology Accumulated evidence has revealed that F-box protein, a subunit of SCF E3 ubiquitin ligase complexes, participates in carcinogenesis and tumor progression via targeting its substrates for ubiquitination and degradation. F-box proteins could be regulated by cellular signaling pathways and noncoding RNAs in tumorigenesis. Long noncoding RNA (lncRNA), one type of noncoding RNAs, has been identified to modulate the expression of F-box proteins and contribute to oncogenesis. In this review, we summarize the role and mechanisms of multiple lncRNAs in regulating F-box proteins in tumorigenesis, including lncRNAs SLC7A11-AS1, MT1JP, TUG1, FER1L4, TTN-AS1, CASC2, MALAT1, TINCR, PCGEM1, linc01436, linc00494, GATA6-AS1, and ODIR1. Moreover, we discuss that targeting these lncRNAs could be helpful for treating cancer via modulating F-box protein expression. We hope our review can stimulate the research on exploration of molecular insight into how F-box proteins are governed in carcinogenesis. Therefore, modulation of lncRNAs is a potential therapeutic strategy for cancer therapy via regulation of F-box proteins. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9343830/ /pubmed/35928868 http://dx.doi.org/10.3389/fonc.2022.963617 Text en Copyright © 2022 Xia, Chen, Huang, Mei and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xia, Lu
Chen, Jingyun
Huang, Min
Mei, Jie
Lin, Min
The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression
title The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression
title_full The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression
title_fullStr The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression
title_full_unstemmed The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression
title_short The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression
title_sort functions of long noncoding rnas on regulation of f-box proteins in tumorigenesis and progression
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343830/
https://www.ncbi.nlm.nih.gov/pubmed/35928868
http://dx.doi.org/10.3389/fonc.2022.963617
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