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Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy
Cognitive impairment and neuropsychiatric disorders are very common in patients with temporal lobe epilepsy (TLE). These comorbidities complicate the treatment of epilepsy and seriously affect the quality of life. So far, there is still no effective intervention to prevent the development of epileps...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343833/ https://www.ncbi.nlm.nih.gov/pubmed/35928136 http://dx.doi.org/10.3389/fneur.2022.948599 |
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author | Wang, Xue Ma, Rui Liu, Xinyi Zhang, Yongbo |
author_facet | Wang, Xue Ma, Rui Liu, Xinyi Zhang, Yongbo |
author_sort | Wang, Xue |
collection | PubMed |
description | Cognitive impairment and neuropsychiatric disorders are very common in patients with temporal lobe epilepsy (TLE). These comorbidities complicate the treatment of epilepsy and seriously affect the quality of life. So far, there is still no effective intervention to prevent the development of epilepsy-associated comorbidities. Gut dysbiosis has been recognized to be involved in the pathology of epilepsy development. Modulating gut microbiota by probiotics has shown an antiseizure effect on humans and animals with epilepsy. Whether this treatment strategy has a positive effect on epilepsy-associated comorbidities remains unclear. Therefore, this study aimed to objectively assess the effect of probiotics on cognitive function and neuropsychiatric performance of patients with TLE. Participants enrolled in an epilepsy clinic were randomly assigned to the probiotic and placebo groups. These two groups were treated with probiotics or placebo for 12 weeks, and then the cognitive function and psychological performance of participants were assessed. We enrolled 76 participants in this study, and 70 subjects were finally included in the study (35 in the probiotics group and 35 in the placebo group). Our results showed significant seizure reduction in patients with TLE treated with probiotics. No significant differences were observed on cognitive function (including intelligence and memory) between groups. For neuropsychiatric performances, supplementation of probiotics significantly decreased the Hamilton Anxiety Rating and Depression Scale scores and increased the 89-item Quality of Life in Epilepsy Inventory score in patients with TLE. In conclusion, probiotics have a positive impact on seizures control, and improve anxiety, depression, and quality of life in patients with TLE. |
format | Online Article Text |
id | pubmed-9343833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93438332022-08-03 Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy Wang, Xue Ma, Rui Liu, Xinyi Zhang, Yongbo Front Neurol Neurology Cognitive impairment and neuropsychiatric disorders are very common in patients with temporal lobe epilepsy (TLE). These comorbidities complicate the treatment of epilepsy and seriously affect the quality of life. So far, there is still no effective intervention to prevent the development of epilepsy-associated comorbidities. Gut dysbiosis has been recognized to be involved in the pathology of epilepsy development. Modulating gut microbiota by probiotics has shown an antiseizure effect on humans and animals with epilepsy. Whether this treatment strategy has a positive effect on epilepsy-associated comorbidities remains unclear. Therefore, this study aimed to objectively assess the effect of probiotics on cognitive function and neuropsychiatric performance of patients with TLE. Participants enrolled in an epilepsy clinic were randomly assigned to the probiotic and placebo groups. These two groups were treated with probiotics or placebo for 12 weeks, and then the cognitive function and psychological performance of participants were assessed. We enrolled 76 participants in this study, and 70 subjects were finally included in the study (35 in the probiotics group and 35 in the placebo group). Our results showed significant seizure reduction in patients with TLE treated with probiotics. No significant differences were observed on cognitive function (including intelligence and memory) between groups. For neuropsychiatric performances, supplementation of probiotics significantly decreased the Hamilton Anxiety Rating and Depression Scale scores and increased the 89-item Quality of Life in Epilepsy Inventory score in patients with TLE. In conclusion, probiotics have a positive impact on seizures control, and improve anxiety, depression, and quality of life in patients with TLE. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9343833/ /pubmed/35928136 http://dx.doi.org/10.3389/fneur.2022.948599 Text en Copyright © 2022 Wang, Ma, Liu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Wang, Xue Ma, Rui Liu, Xinyi Zhang, Yongbo Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
title | Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
title_full | Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
title_fullStr | Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
title_full_unstemmed | Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
title_short | Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
title_sort | effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343833/ https://www.ncbi.nlm.nih.gov/pubmed/35928136 http://dx.doi.org/10.3389/fneur.2022.948599 |
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