Cargando…

Platelet depletion does not alter long-term functional outcome after cerebral ischaemia in mice

Platelets are key mediators of thrombus formation and inflammation during the acute phase of ischaemic stroke. Particularly, the platelet glycoprotein (GP) receptors GPIbα and GPVI have been shown to mediate platelet adhesion and activation in the ischaemic brain. GPIbα and GPVI blockade could reduc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steubing, Rebecca D., Szepanowski, Fabian, David, Christina, Mohamud Yusuf, Ayan, Mencl, Stine, Mausberg, Anne-Kathrin, Langer, Harald F., Sauter, Manuela, Deuschl, Cornelius, Forsting, Michael, Fender, Anke C., Hermann, Dirk M., Casas, Ana I., Langhauser, Friederike, Kleinschnitz, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343933/ https://www.ncbi.nlm.nih.gov/pubmed/35928516 http://dx.doi.org/10.1016/j.bbih.2022.100493

Ejemplares similares

Impact of NKG2D Signaling on Natural Killer and T‐Cell Function in Cerebral Ischemia
por: David, Christina, et al.
Publicado: (2023)

LPA(1) signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis
por: Szepanowski, Fabian, et al.
Publicado: (2021)

High-dose biotin neither fosters remyelination nor stimulates malonyl coenzyme A synthesis in the regenerating nerve
por: Szepanowski, Fabian, et al.
Publicado: (2022)

Oropharyngeal swab for SARS-CoV-2 test causing atypical internal carotid artery dissection and stroke in a patient after mild COVID-19
por: Asan, Livia, et al.
Publicado: (2021)

Time for a standardized diagnostic response test in patients with chronic inflammatory demyelinating polyradiculoneuropathy?
por: Szepanowski, Fabian, et al.
Publicado: (2023)

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation
por: Albert-Weissenberger, Christiane, et al.
Publicado: (2014)

Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis
por: Mausberg, Anne K., et al.
Publicado: (2018)

B cells do not have a major pathophysiologic role in acute ischemic stroke in mice
por: Schuhmann, Michael K., et al.
Publicado: (2017)

Secondary Immunodeficiency and Risk of Infection Following Immune Therapies in Neurology
por: Szepanowski, Fabian, et al.
Publicado: (2021)

Post-COVID-19 Syndrome is Rarely Associated with Damage of the Nervous System: Findings from a Prospective Observational Cohort Study in 171 Patients
por: Fleischer, Michael, et al.
Publicado: (2022)

Severe and long-lasting alteration of albumin redox state by plasmapheresis
por: Boss, Kristina, et al.
Publicado: (2022)

Role of the kallikrein–kinin system in traumatic brain injury
por: Albert-Weissenberger, Christiane, et al.
Publicado: (2014)

Dimethyl Fumarate Attenuates Lymphocyte Infiltration and Reduces Infarct Size in Experimental Stroke
por: Schuhmann, Michael K., et al.
Publicado: (2023)

Glyphosate-based herbicide: a risk factor for demyelinating conditions of the peripheral nervous system?
por: Szepanowski, Fabian, et al.
Publicado: (2019)

Thromboinflammatory challenges in stroke pathophysiology
por: Szepanowski, R.D, et al.
Publicado: (2023)

Post-Contrast Acute Kidney Injury after Acute Stroke—Insights from a German Tertiary Care Center
por: Frank, Benedikt, et al.
Publicado: (2021)

Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/anti-SOX1 and VGCC antibodies
por: Feldheim, Jonas, et al.
Publicado: (2021)

Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia
por: Malone, Kyle, et al.
Publicado: (2022)

NK cell markers predict the efficacy of IV immunoglobulins in CIDP
por: Mausberg, Anne K., et al.
Publicado: (2020)

FAST-ED scale smartphone app-based prediction of large vessel occlusion in suspected stroke by emergency medical service
por: Frank, Benedikt, et al.
Publicado: (2021)

Single- and Dual-Source CT Myelography: Comparison of Radiation Exposure and Establishment of Diagnostic Reference Levels
por: Zensen, Sebastian, et al.
Publicado: (2021)

Influence of Deuterium-Depleted Water on the Isotope D/H Composition of Liver Tissue and Morphological Development of Rats at Different Periods of Ontogenesis
por: Alexandrovich Basov, Alexandr, et al.
Publicado: (2019)

A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and increased survival
por: Casas, Ana I, et al.
Publicado: (2015)

Assessment of Health-Related Quality of Life in Adult Spinal Muscular Atrophy Under Nusinersen Treatment—A Pilot Study
por: Thimm, Andreas, et al.
Publicado: (2022)

Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia
por: Hagemann, Nina, et al.
Publicado: (2020)

ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke
por: Schanbacher, Constanze, et al.
Publicado: (2022)

Breakthrough SARS‐CoV‐2 infections in immune mediated disease patients undergoing B cell depleting therapy: A retrospective cohort analysis
por: Calabrese, Cassandra M, et al.
Publicado: (2022)

Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters
por: Stolte, Benjamin, et al.
Publicado: (2021)

Radiation exposure of computed tomography imaging for the assessment of acute stroke
por: Zensen, Sebastian, et al.
Publicado: (2020)

Observational cohort study of neurological involvement among patients with SARS-CoV-2 infection
por: Fleischer, Michael, et al.
Publicado: (2021)

Treatment of acute ischemic stroke in patients with active malignancy: insight from a comprehensive stroke center
por: Chae, Woon Hyung, et al.
Publicado: (2023)

Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway
por: Liu, Yi, et al.
Publicado: (2020)

Predictors of Covid-19 Vaccination Response After In-Vivo T-Cell–Depleted Stem Cell Transplantation
por: Chaekal, Ok-kyong, et al.
Publicado: (2022)

Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis
por: Li, Zhongxian, et al.
Publicado: (2023)

Frequency and Characteristics of Non-Neurological and Neurological Stroke Mimics in the Emergency Department
por: Kühne Escolà, Jordi, et al.
Publicado: (2023)

The accuracy of clinical neck staging for p16-positive and negative oropharyngeal cancer and its therapeutic implications
por: Hussain, Timon, et al.
Publicado: (2022)

Increases survival by apo-sGC activation via post-stroke blood brain barrier stabilisation and anti-inflammation
por: Langhauser, Friedericke, et al.
Publicado: (2013)

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
por: Casas, Ana I., et al.
Publicado: (2017)

Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats
por: Mencl, Stine, et al.
Publicado: (2013)

A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection
por: Langhauser, Friederike, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bqgiqv5eam0v4o8uheivtd13st