Population Pharmacokinetics and Pharmacodynamics of Isoniazid and its Metabolite Acetylisoniazid in Chinese Population

Objective: We aimed to establish a population pharmacokinetic (PPK) model for isoniazid (INH) and its major metabolite Acetylisoniazid (AcINH) in healthy Chinese participants and tuberculosis patients and assess the role of the NAT2 genotype on the transformation of INH to AcINH. We also sought to e...

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Detalles Bibliográficos
Autores principales: Chen, Bing, Shi, Hao-Qiang, Feng, Meihua Rose, Wang, Xi-Han, Cao, Xiao-Mei, Cai, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343941/
https://www.ncbi.nlm.nih.gov/pubmed/35928262
http://dx.doi.org/10.3389/fphar.2022.932686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343941/
https://www.ncbi.nlm.nih.gov/pubmed/35928262
http://dx.doi.org/10.3389/fphar.2022.932686

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