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Effect of Cholesterol on C99 Dimerization: Revealed by Molecular Dynamics Simulations

C99 is the immediate precursor for amyloid beta (Aβ) and therefore is a central intermediate in the pathway that is believed to result in Alzheimer’s disease (AD). It has been suggested that cholesterol is associated with C99, but the dynamic details of how cholesterol affects C99 assembly and the A...

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Detalles Bibliográficos
Autores principales:	Li, Cheng-Dong, Junaid, Muhammad, Shan, Xiaoqi, Wang, Yanjing, Wang, Xiangeng, Khan, Abbas, Wei, Dong-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343951/ https://www.ncbi.nlm.nih.gov/pubmed/35928227 http://dx.doi.org/10.3389/fmolb.2022.872385

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