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Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study

Alterations in the oral microbiota composition may influence mental health. However, linkages between compositional changes in the oral microbiota and their role in mental health among cigarette smokers remain largely unknown. In this study, we used shotgun metagenomics data for the oral microbiome...

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Autores principales: Al Bataineh, Mohammad Tahseen, Künstner, Axel, Dash, Nihar Ranjan, Abdulsalam, Rushud Mahmood, Al-Kayyali, Rafla Zaid Ali, Adi, M. Besher, Alsafar, Habiba S., Busch, Hauke, Ibrahim, Saleh Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343996/
https://www.ncbi.nlm.nih.gov/pubmed/35928781
http://dx.doi.org/10.3389/fpsyt.2022.902433
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author Al Bataineh, Mohammad Tahseen
Künstner, Axel
Dash, Nihar Ranjan
Abdulsalam, Rushud Mahmood
Al-Kayyali, Rafla Zaid Ali
Adi, M. Besher
Alsafar, Habiba S.
Busch, Hauke
Ibrahim, Saleh Mohamed
author_facet Al Bataineh, Mohammad Tahseen
Künstner, Axel
Dash, Nihar Ranjan
Abdulsalam, Rushud Mahmood
Al-Kayyali, Rafla Zaid Ali
Adi, M. Besher
Alsafar, Habiba S.
Busch, Hauke
Ibrahim, Saleh Mohamed
author_sort Al Bataineh, Mohammad Tahseen
collection PubMed
description Alterations in the oral microbiota composition may influence mental health. However, linkages between compositional changes in the oral microbiota and their role in mental health among cigarette smokers remain largely unknown. In this study, we used shotgun metagenomics data for the oral microbiome of 105 participants. The data showed Bacteroidota, Fusobacteriota, Firmicutes, Proteobacteria, and Actinobacteria to be the most abundant phyla; Streptococcus, Haemophilus D, and Veillonella are the most abundant genera. Then, we clustered our subjects into avoidance and activation groups based on the behavioral activation for depression scale (BADS). Interestingly, the avoidance group exhibited a higher oral microbiome richness and diversity (alpha diversity). Differential abundance testing between BADS avoidance and activation groups showed the phyla Bacteroidota (effect size 0.5047, q = 0.0037), Campylobacterota (effect size 0.4012, q = 0.0276), Firmicutes A (effect size 0.3646, q = 0.0128), Firmicutes I (effect size 0.3581, q = 0.0268), and Fusobacteriota (effect size 0.6055, q = 0.0018) to be significantly increased in the avoidance group, but Verrucomicrobiota (effect size−0.6544, q = 0.0401), was found to be significantly decreased in the avoidance risk group. Network analysis of the 50 genera displaying the highest variation between both groups identified Campylobacter B, Centipeda, and Veillonella as hub nodes in the avoidance group. In contrast, Haemophilus and Streptococcus were identified as hub nodes in the activation group. Next, we investigated functional profiles of the oral microbiota based on BADS avoidance and activation groups and found Lysine degradations pathway was significantly enriched between both groups (ANCOM-BC, q = 0.0692). Altogether, we provide evidence for the presence of depression-related changes in the oral microbiota of smokers and possible functional contribution. The identified differences provide new information to enrich our understanding of oral microbiota-brain axis interplay and their potential impact on mental health.
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spelling pubmed-93439962022-08-03 Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study Al Bataineh, Mohammad Tahseen Künstner, Axel Dash, Nihar Ranjan Abdulsalam, Rushud Mahmood Al-Kayyali, Rafla Zaid Ali Adi, M. Besher Alsafar, Habiba S. Busch, Hauke Ibrahim, Saleh Mohamed Front Psychiatry Psychiatry Alterations in the oral microbiota composition may influence mental health. However, linkages between compositional changes in the oral microbiota and their role in mental health among cigarette smokers remain largely unknown. In this study, we used shotgun metagenomics data for the oral microbiome of 105 participants. The data showed Bacteroidota, Fusobacteriota, Firmicutes, Proteobacteria, and Actinobacteria to be the most abundant phyla; Streptococcus, Haemophilus D, and Veillonella are the most abundant genera. Then, we clustered our subjects into avoidance and activation groups based on the behavioral activation for depression scale (BADS). Interestingly, the avoidance group exhibited a higher oral microbiome richness and diversity (alpha diversity). Differential abundance testing between BADS avoidance and activation groups showed the phyla Bacteroidota (effect size 0.5047, q = 0.0037), Campylobacterota (effect size 0.4012, q = 0.0276), Firmicutes A (effect size 0.3646, q = 0.0128), Firmicutes I (effect size 0.3581, q = 0.0268), and Fusobacteriota (effect size 0.6055, q = 0.0018) to be significantly increased in the avoidance group, but Verrucomicrobiota (effect size−0.6544, q = 0.0401), was found to be significantly decreased in the avoidance risk group. Network analysis of the 50 genera displaying the highest variation between both groups identified Campylobacter B, Centipeda, and Veillonella as hub nodes in the avoidance group. In contrast, Haemophilus and Streptococcus were identified as hub nodes in the activation group. Next, we investigated functional profiles of the oral microbiota based on BADS avoidance and activation groups and found Lysine degradations pathway was significantly enriched between both groups (ANCOM-BC, q = 0.0692). Altogether, we provide evidence for the presence of depression-related changes in the oral microbiota of smokers and possible functional contribution. The identified differences provide new information to enrich our understanding of oral microbiota-brain axis interplay and their potential impact on mental health. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9343996/ /pubmed/35928781 http://dx.doi.org/10.3389/fpsyt.2022.902433 Text en Copyright © 2022 Al Bataineh, Künstner, Dash, Abdulsalam, Al-Kayyali, Adi, Alsafar, Busch and Ibrahim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Al Bataineh, Mohammad Tahseen
Künstner, Axel
Dash, Nihar Ranjan
Abdulsalam, Rushud Mahmood
Al-Kayyali, Rafla Zaid Ali
Adi, M. Besher
Alsafar, Habiba S.
Busch, Hauke
Ibrahim, Saleh Mohamed
Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study
title Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study
title_full Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study
title_fullStr Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study
title_full_unstemmed Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study
title_short Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study
title_sort altered composition of the oral microbiota in depression among cigarette smokers: a pilot study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343996/
https://www.ncbi.nlm.nih.gov/pubmed/35928781
http://dx.doi.org/10.3389/fpsyt.2022.902433
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