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Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease
Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological and neurochemical processes, including those subserving cognitive function. Estradiol plays a key role in the neurobiology of aging, in part due to extensive interconnectivity of the neural and endocrine system...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344010/ https://www.ncbi.nlm.nih.gov/pubmed/35928995 http://dx.doi.org/10.3389/fnagi.2022.948219 |
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author | Jett, Steven Schelbaum, Eva Jang, Grace Boneu Yepez, Camila Dyke, Jonathan P. Pahlajani, Silky Diaz Brinton, Roberta Mosconi, Lisa |
author_facet | Jett, Steven Schelbaum, Eva Jang, Grace Boneu Yepez, Camila Dyke, Jonathan P. Pahlajani, Silky Diaz Brinton, Roberta Mosconi, Lisa |
author_sort | Jett, Steven |
collection | PubMed |
description | Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological and neurochemical processes, including those subserving cognitive function. Estradiol plays a key role in the neurobiology of aging, in part due to extensive interconnectivity of the neural and endocrine system. This aspect of aging is fundamental for women’s brains as all women experience a drop in circulating estradiol levels in midlife, after menopause. Given the importance of estradiol for brain function, it is not surprising that up to 80% of peri-menopausal and post-menopausal women report neurological symptoms including changes in thermoregulation (vasomotor symptoms), mood, sleep, and cognitive performance. Preclinical evidence for neuroprotective effects of 17β-estradiol also indicate associations between menopause, cognitive aging, and Alzheimer’s disease (AD), the most common cause of dementia affecting nearly twice more women than men. Brain imaging studies demonstrated that middle-aged women exhibit increased indicators of AD endophenotype as compared to men of the same age, with onset in perimenopause. Herein, we take a translational approach to illustrate the contribution of ovarian hormones in maintaining cognition in women, with evidence implicating menopause-related declines in 17β-estradiol in cognitive aging and AD risk. We will review research focused on the role of endogenous and exogenous estrogen exposure as a key underlying mechanism to neuropathological aging in women, with a focus on whether brain structure, function and neurochemistry respond to hormone treatment. While still in development, this research area offers a new sex-based perspective on brain aging and risk of AD, while also highlighting an urgent need for better integration between neurology, psychiatry, and women’s health practices. |
format | Online Article Text |
id | pubmed-9344010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93440102022-08-03 Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease Jett, Steven Schelbaum, Eva Jang, Grace Boneu Yepez, Camila Dyke, Jonathan P. Pahlajani, Silky Diaz Brinton, Roberta Mosconi, Lisa Front Aging Neurosci Neuroscience Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological and neurochemical processes, including those subserving cognitive function. Estradiol plays a key role in the neurobiology of aging, in part due to extensive interconnectivity of the neural and endocrine system. This aspect of aging is fundamental for women’s brains as all women experience a drop in circulating estradiol levels in midlife, after menopause. Given the importance of estradiol for brain function, it is not surprising that up to 80% of peri-menopausal and post-menopausal women report neurological symptoms including changes in thermoregulation (vasomotor symptoms), mood, sleep, and cognitive performance. Preclinical evidence for neuroprotective effects of 17β-estradiol also indicate associations between menopause, cognitive aging, and Alzheimer’s disease (AD), the most common cause of dementia affecting nearly twice more women than men. Brain imaging studies demonstrated that middle-aged women exhibit increased indicators of AD endophenotype as compared to men of the same age, with onset in perimenopause. Herein, we take a translational approach to illustrate the contribution of ovarian hormones in maintaining cognition in women, with evidence implicating menopause-related declines in 17β-estradiol in cognitive aging and AD risk. We will review research focused on the role of endogenous and exogenous estrogen exposure as a key underlying mechanism to neuropathological aging in women, with a focus on whether brain structure, function and neurochemistry respond to hormone treatment. While still in development, this research area offers a new sex-based perspective on brain aging and risk of AD, while also highlighting an urgent need for better integration between neurology, psychiatry, and women’s health practices. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9344010/ /pubmed/35928995 http://dx.doi.org/10.3389/fnagi.2022.948219 Text en Copyright © 2022 Jett, Schelbaum, Jang, Boneu Yepez, Dyke, Pahlajani, Diaz Brinton and Mosconi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Jett, Steven Schelbaum, Eva Jang, Grace Boneu Yepez, Camila Dyke, Jonathan P. Pahlajani, Silky Diaz Brinton, Roberta Mosconi, Lisa Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease |
title | Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease |
title_full | Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease |
title_fullStr | Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease |
title_full_unstemmed | Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease |
title_short | Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease |
title_sort | ovarian steroid hormones: a long overlooked but critical contributor to brain aging and alzheimer’s disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344010/ https://www.ncbi.nlm.nih.gov/pubmed/35928995 http://dx.doi.org/10.3389/fnagi.2022.948219 |
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