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Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon
Increased blood pressure (BP) has been associated with higher risk of stroke and mortality in Sickle Cell Disease (SCD). We investigated risk factors associated with Relative Systemic Hypertension (RSH) or systemic hypertension in SCD patients in Cameroon. Using R, Multivariate multinomial logistic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344053/ https://www.ncbi.nlm.nih.gov/pubmed/35928290 http://dx.doi.org/10.3389/fmed.2022.924722 |
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author | Nguweneza, Arthemon Ngo Bitoungui, Valentina Josiane Mnika, Khuthala Mazandu, Gaston Nembaware, Victoria Kengne, Andre P. Wonkam, Ambroise |
author_facet | Nguweneza, Arthemon Ngo Bitoungui, Valentina Josiane Mnika, Khuthala Mazandu, Gaston Nembaware, Victoria Kengne, Andre P. Wonkam, Ambroise |
author_sort | Nguweneza, Arthemon |
collection | PubMed |
description | Increased blood pressure (BP) has been associated with higher risk of stroke and mortality in Sickle Cell Disease (SCD). We investigated risk factors associated with Relative Systemic Hypertension (RSH) or systemic hypertension in SCD patients in Cameroon. Using R, Multivariate multinomial logistic regression modeling was used to examine the effects of the demographic, anthropometric, clinical, and laboratory factors to determine risk factors. A total of 815 individuals with SCD, including 380 (46.6%) males were analyzed. At baseline, the median age [interquartile range] was 18.0 [12.0–25.0] years, ranging from 3 to 66 years. Approximately three-quarters of the patients (n = 645; 79.1%) had normal BP, 151 (18.5%) had RSH and 19 (2.3%) had hypertension. Age (P < 0.001) and gender (P = 0.022) were significantly different across the BP categories. Weight (P < 0.001), height (P < 0.001), BMI (P < 0.001), pulse pressure (P = 0.020), history of stroke (P = 0.012), hemoglobin level (P = 0.002), red blood cell count (P = 0.031), creatinine (P < 0.001), and (estimated glomerular filtration rate) eGFR (P = 0.002) was also significantly different across the three BP categories. After adjustment, the significantly associated factors of RSH in the SCD patients were age [OR = 1.03, (95% CI = 1.01–1.06), P < 0.010], male gender [OR = 1.54, (95% CI = 1.04–2.27), P = 0.029], BMI [OR = 1.10, (95% CI = 1.04–1.17), P = 0.001]. After adjustment, the independent variables significantly associated factors of Hypertension in the SCD patients were age [OR = 1.05, (95% CI = 1.01–1.10), P = 0.034], male gender [OR = 3.31, (95% CI = 1.04–10.52), P = 0.042], BMI [OR = 1.14, (95% CI = 1.01–1.29), P = 0.027]. Creatinine was significantly associated with RSH [OR =1.31 (1.05–1.63), P = 0.016]. SCD patients with RSH or hypertension maybe at increased risk of renal dysfunction. We found relatively high prevalence of RSH and hypertension (20.8%) in SCD patients in Cameroon. Tailored Interventions that consider major risk factors (age, gender, and BMI) may lower BP pressure and prevent severe complications. |
format | Online Article Text |
id | pubmed-9344053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93440532022-08-03 Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon Nguweneza, Arthemon Ngo Bitoungui, Valentina Josiane Mnika, Khuthala Mazandu, Gaston Nembaware, Victoria Kengne, Andre P. Wonkam, Ambroise Front Med (Lausanne) Medicine Increased blood pressure (BP) has been associated with higher risk of stroke and mortality in Sickle Cell Disease (SCD). We investigated risk factors associated with Relative Systemic Hypertension (RSH) or systemic hypertension in SCD patients in Cameroon. Using R, Multivariate multinomial logistic regression modeling was used to examine the effects of the demographic, anthropometric, clinical, and laboratory factors to determine risk factors. A total of 815 individuals with SCD, including 380 (46.6%) males were analyzed. At baseline, the median age [interquartile range] was 18.0 [12.0–25.0] years, ranging from 3 to 66 years. Approximately three-quarters of the patients (n = 645; 79.1%) had normal BP, 151 (18.5%) had RSH and 19 (2.3%) had hypertension. Age (P < 0.001) and gender (P = 0.022) were significantly different across the BP categories. Weight (P < 0.001), height (P < 0.001), BMI (P < 0.001), pulse pressure (P = 0.020), history of stroke (P = 0.012), hemoglobin level (P = 0.002), red blood cell count (P = 0.031), creatinine (P < 0.001), and (estimated glomerular filtration rate) eGFR (P = 0.002) was also significantly different across the three BP categories. After adjustment, the significantly associated factors of RSH in the SCD patients were age [OR = 1.03, (95% CI = 1.01–1.06), P < 0.010], male gender [OR = 1.54, (95% CI = 1.04–2.27), P = 0.029], BMI [OR = 1.10, (95% CI = 1.04–1.17), P = 0.001]. After adjustment, the independent variables significantly associated factors of Hypertension in the SCD patients were age [OR = 1.05, (95% CI = 1.01–1.10), P = 0.034], male gender [OR = 3.31, (95% CI = 1.04–10.52), P = 0.042], BMI [OR = 1.14, (95% CI = 1.01–1.29), P = 0.027]. Creatinine was significantly associated with RSH [OR =1.31 (1.05–1.63), P = 0.016]. SCD patients with RSH or hypertension maybe at increased risk of renal dysfunction. We found relatively high prevalence of RSH and hypertension (20.8%) in SCD patients in Cameroon. Tailored Interventions that consider major risk factors (age, gender, and BMI) may lower BP pressure and prevent severe complications. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9344053/ /pubmed/35928290 http://dx.doi.org/10.3389/fmed.2022.924722 Text en Copyright © 2022 Nguweneza, Ngo Bitoungui, Mnika, Mazandu, Nembaware, Kengne and Wonkam. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Nguweneza, Arthemon Ngo Bitoungui, Valentina Josiane Mnika, Khuthala Mazandu, Gaston Nembaware, Victoria Kengne, Andre P. Wonkam, Ambroise Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon |
title | Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon |
title_full | Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon |
title_fullStr | Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon |
title_full_unstemmed | Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon |
title_short | Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon |
title_sort | clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in cameroon |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344053/ https://www.ncbi.nlm.nih.gov/pubmed/35928290 http://dx.doi.org/10.3389/fmed.2022.924722 |
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