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Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center

Only a few clusters of invasive pneumococcal disease have been described globally in children, and most of these cases occurred before pneumococcal vaccination implementation. Two unusual cases of pneumococcal meningitis, occurring in the same daycare center over a 3-day period, were reported. Both...

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Autores principales: Rybak, Alexis, Varon, Emmanuelle, Masson, Elodie, Etchevers, Anne, Levy-Brühl, Daniel, Ouldali, Naïm, Levy, Corinne, Cohen, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344131/
https://www.ncbi.nlm.nih.gov/pubmed/35928689
http://dx.doi.org/10.3389/fped.2022.945767
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author Rybak, Alexis
Varon, Emmanuelle
Masson, Elodie
Etchevers, Anne
Levy-Brühl, Daniel
Ouldali, Naïm
Levy, Corinne
Cohen, Robert
author_facet Rybak, Alexis
Varon, Emmanuelle
Masson, Elodie
Etchevers, Anne
Levy-Brühl, Daniel
Ouldali, Naïm
Levy, Corinne
Cohen, Robert
author_sort Rybak, Alexis
collection PubMed
description Only a few clusters of invasive pneumococcal disease have been described globally in children, and most of these cases occurred before pneumococcal vaccination implementation. Two unusual cases of pneumococcal meningitis, occurring in the same daycare center over a 3-day period, were reported. Both cerebrospinal fluid (CSF) were sent to the National reference center for pneumococci. In addition, we decided to perform a pneumococcal carriage study on all children and staff of the daycare center to analyze the pneumococcal serotypes circulating in this DCC and to discuss an antibiotic chemoprophylaxis. CSF culture was positive for pneumococcus, and serotype 25A was identified by latex agglutination. The second case had negative CSF culture, but CSF antigen test and gene amplification results were positive for Streptococcus pneumoniae. Serotype 12F was identified by using molecular biology. The absence of correlation between these strains was confirmed by multi-locus sequence typing. In the carriage study, we included 29 children (median age 1.9 years, interquartile range 1.4–2.5) and 10 adults. Among the children, 24 carried Streptococcus pneumoniae (83%). The main serotypes isolated were 23A for 6 children and 25A for 5 children; serotypes were non-typeable for 3 children. Only 1 of 10 adults tested carried Streptococcus pneumoniae (serotype 12F). Despite this temporo-spatial pattern, the cases were unrelated and not due to carriage of a particular serotype. No specific action has been taken for the other children attending this DCC, and no other case of bacterial meningitis occurred.
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spelling pubmed-93441312022-08-03 Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center Rybak, Alexis Varon, Emmanuelle Masson, Elodie Etchevers, Anne Levy-Brühl, Daniel Ouldali, Naïm Levy, Corinne Cohen, Robert Front Pediatr Pediatrics Only a few clusters of invasive pneumococcal disease have been described globally in children, and most of these cases occurred before pneumococcal vaccination implementation. Two unusual cases of pneumococcal meningitis, occurring in the same daycare center over a 3-day period, were reported. Both cerebrospinal fluid (CSF) were sent to the National reference center for pneumococci. In addition, we decided to perform a pneumococcal carriage study on all children and staff of the daycare center to analyze the pneumococcal serotypes circulating in this DCC and to discuss an antibiotic chemoprophylaxis. CSF culture was positive for pneumococcus, and serotype 25A was identified by latex agglutination. The second case had negative CSF culture, but CSF antigen test and gene amplification results were positive for Streptococcus pneumoniae. Serotype 12F was identified by using molecular biology. The absence of correlation between these strains was confirmed by multi-locus sequence typing. In the carriage study, we included 29 children (median age 1.9 years, interquartile range 1.4–2.5) and 10 adults. Among the children, 24 carried Streptococcus pneumoniae (83%). The main serotypes isolated were 23A for 6 children and 25A for 5 children; serotypes were non-typeable for 3 children. Only 1 of 10 adults tested carried Streptococcus pneumoniae (serotype 12F). Despite this temporo-spatial pattern, the cases were unrelated and not due to carriage of a particular serotype. No specific action has been taken for the other children attending this DCC, and no other case of bacterial meningitis occurred. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9344131/ /pubmed/35928689 http://dx.doi.org/10.3389/fped.2022.945767 Text en Copyright © 2022 Rybak, Varon, Masson, Etchevers, Levy-Brühl, Ouldali, Levy and Cohen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Rybak, Alexis
Varon, Emmanuelle
Masson, Elodie
Etchevers, Anne
Levy-Brühl, Daniel
Ouldali, Naïm
Levy, Corinne
Cohen, Robert
Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center
title Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center
title_full Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center
title_fullStr Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center
title_full_unstemmed Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center
title_short Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center
title_sort investigation of concurrent pneumococcal meningitis in two children attending the same day-care center
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344131/
https://www.ncbi.nlm.nih.gov/pubmed/35928689
http://dx.doi.org/10.3389/fped.2022.945767
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