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Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma

PURPOSE: To test the hypothesis that newly developed shape measures using optical coherence tomography (OCT) macular volume scans can discriminate patients with perimetric glaucoma from healthy subjects. METHODS: OCT structural measures defining macular topography and volume were recently developed...

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Autores principales: Mohammadzadeh, Vahid, Cheng, Melodyanne, Zadeh, Sepideh Heydar, Edalati, Kiumars, Yalzadeh, Dariush, Caprioli, Joseph, Yadav, Sunil, Kadas, Ella M., Brandt, Alexander U., Nouri-Mahdavi, Kouros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344219/
https://www.ncbi.nlm.nih.gov/pubmed/35904793
http://dx.doi.org/10.1167/tvst.11.7.25
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author Mohammadzadeh, Vahid
Cheng, Melodyanne
Zadeh, Sepideh Heydar
Edalati, Kiumars
Yalzadeh, Dariush
Caprioli, Joseph
Yadav, Sunil
Kadas, Ella M.
Brandt, Alexander U.
Nouri-Mahdavi, Kouros
author_facet Mohammadzadeh, Vahid
Cheng, Melodyanne
Zadeh, Sepideh Heydar
Edalati, Kiumars
Yalzadeh, Dariush
Caprioli, Joseph
Yadav, Sunil
Kadas, Ella M.
Brandt, Alexander U.
Nouri-Mahdavi, Kouros
author_sort Mohammadzadeh, Vahid
collection PubMed
description PURPOSE: To test the hypothesis that newly developed shape measures using optical coherence tomography (OCT) macular volume scans can discriminate patients with perimetric glaucoma from healthy subjects. METHODS: OCT structural measures defining macular topography and volume were recently developed based on cubic Bézier curves. We exported macular volume scans from 135 eyes with glaucoma (133 patients) and 155 healthy eyes (85 subjects) and estimated global and quadrant-based measures. The best subset of measures to predict glaucoma was explored with a gradient boost model (GBM) with subsequent logistic regression. Accuracy and area under receiver operating curves (AUC) were the primary metrics. In addition, we separately investigated model performance in 66 eyes with mild glaucoma (mean deviation ≥ –6 dB). RESULTS: Average (±SD) 24-2 mean deviation was –8.2 (±6.1) dB in eyes with glaucoma. The main predictive measures for glaucoma were temporal inferior rim height, nasal inferior pit volume, and temporal inferior pit depth. Lower values for these measures predicted higher risk of glaucoma. Sensitivity, specificity, and AUC for discriminating between healthy and glaucoma eyes were 81.5% (95% CI = 76.6–91.9%), 89.7% (95% CI = 78.7–94.2%), and 0.915 (95% CI = 0.882–0.948), respectively. Corresponding metrics for mild glaucoma were 84.8% (95% CI = 72.1%–95.5%), 85.8% (95% CI = 87.1%–97.4%), and 0.913 (95% CI = 0.867–0.958), respectively. CONCLUSIONS: Novel macular shape biomarkers detect early glaucoma with clinically relevant performance. Such biomarkers do not depend on intraretinal segmentation accuracy and may be helpful in eyes with suboptimal macular segmentation. TRANSLATIONAL RELEVANCE: Macular shape biomarkers provide valuable information for detection of early glaucoma and may provide additional information beyond thickness measurements.
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spelling pubmed-93442192022-08-03 Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma Mohammadzadeh, Vahid Cheng, Melodyanne Zadeh, Sepideh Heydar Edalati, Kiumars Yalzadeh, Dariush Caprioli, Joseph Yadav, Sunil Kadas, Ella M. Brandt, Alexander U. Nouri-Mahdavi, Kouros Transl Vis Sci Technol Glaucoma PURPOSE: To test the hypothesis that newly developed shape measures using optical coherence tomography (OCT) macular volume scans can discriminate patients with perimetric glaucoma from healthy subjects. METHODS: OCT structural measures defining macular topography and volume were recently developed based on cubic Bézier curves. We exported macular volume scans from 135 eyes with glaucoma (133 patients) and 155 healthy eyes (85 subjects) and estimated global and quadrant-based measures. The best subset of measures to predict glaucoma was explored with a gradient boost model (GBM) with subsequent logistic regression. Accuracy and area under receiver operating curves (AUC) were the primary metrics. In addition, we separately investigated model performance in 66 eyes with mild glaucoma (mean deviation ≥ –6 dB). RESULTS: Average (±SD) 24-2 mean deviation was –8.2 (±6.1) dB in eyes with glaucoma. The main predictive measures for glaucoma were temporal inferior rim height, nasal inferior pit volume, and temporal inferior pit depth. Lower values for these measures predicted higher risk of glaucoma. Sensitivity, specificity, and AUC for discriminating between healthy and glaucoma eyes were 81.5% (95% CI = 76.6–91.9%), 89.7% (95% CI = 78.7–94.2%), and 0.915 (95% CI = 0.882–0.948), respectively. Corresponding metrics for mild glaucoma were 84.8% (95% CI = 72.1%–95.5%), 85.8% (95% CI = 87.1%–97.4%), and 0.913 (95% CI = 0.867–0.958), respectively. CONCLUSIONS: Novel macular shape biomarkers detect early glaucoma with clinically relevant performance. Such biomarkers do not depend on intraretinal segmentation accuracy and may be helpful in eyes with suboptimal macular segmentation. TRANSLATIONAL RELEVANCE: Macular shape biomarkers provide valuable information for detection of early glaucoma and may provide additional information beyond thickness measurements. The Association for Research in Vision and Ophthalmology 2022-07-29 /pmc/articles/PMC9344219/ /pubmed/35904793 http://dx.doi.org/10.1167/tvst.11.7.25 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Glaucoma
Mohammadzadeh, Vahid
Cheng, Melodyanne
Zadeh, Sepideh Heydar
Edalati, Kiumars
Yalzadeh, Dariush
Caprioli, Joseph
Yadav, Sunil
Kadas, Ella M.
Brandt, Alexander U.
Nouri-Mahdavi, Kouros
Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
title Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
title_full Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
title_fullStr Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
title_full_unstemmed Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
title_short Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma
title_sort central macular topographic and volumetric measures: new biomarkers for detection of glaucoma
topic Glaucoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344219/
https://www.ncbi.nlm.nih.gov/pubmed/35904793
http://dx.doi.org/10.1167/tvst.11.7.25
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