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A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations

BACKGROUND/AIMS: Proinflammatory cytokines released from adipocytes can influence the development, progression, and treatment of inflammatory bowel disease (IBD), and may be associated with worse clinical outcomes. METHODS: For 2016–2018, we analyzed data from the Nationwide Inpatient Sample to iden...

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Autores principales: Dahiya, Dushyant Singh, Kichloo, Asim, Wani, Farah, Singh, Jagmeet, Solanki, Dhanshree, Shaka, Hafeez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344244/
https://www.ncbi.nlm.nih.gov/pubmed/34011019
http://dx.doi.org/10.5217/ir.2021.00046
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author Dahiya, Dushyant Singh
Kichloo, Asim
Wani, Farah
Singh, Jagmeet
Solanki, Dhanshree
Shaka, Hafeez
author_facet Dahiya, Dushyant Singh
Kichloo, Asim
Wani, Farah
Singh, Jagmeet
Solanki, Dhanshree
Shaka, Hafeez
author_sort Dahiya, Dushyant Singh
collection PubMed
description BACKGROUND/AIMS: Proinflammatory cytokines released from adipocytes can influence the development, progression, and treatment of inflammatory bowel disease (IBD), and may be associated with worse clinical outcomes. METHODS: For 2016–2018, we analyzed data from the Nationwide Inpatient Sample to identify adult (≥18 years) hospitalizations with a primary discharge diagnosis of IBD. The study sample was divided based on the presence or absence of obesity. The primary outcomes included inpatient mortality, while the secondary outcomes consisted of system-based complications and disease implications on the United States healthcare system. RESULTS: We identified 282,005 hospitalizations of IBD from 2016 to 2018. Of these hospitalizations, 26,465 (9.4%) had a secondary diagnosis of obesity while 255,540 (90.6%) served as controls. IBD hospitalizations with obesity had a higher mean age (47.9 years vs. 45.2 years, P<0.001), middle age (range, 40–65 years) predominance (37.7% vs. 28.9%, P<0.001), female predominance (64.1% vs. 52.5%, P<0.001) and higher proportion of patients with comorbidities compared to the non-obese cohort. White predominance was observed in both subgroups. No difference in the odds of inpatient mortality was noted between the 2 subgroups; however, IBD hospitalizations with obesity had higher mean total hospital charge ($50,126 vs. $45,001, P<0.001), longer length of stay (5.5 days vs. 4.9 days, P<0.001) and higher proportion of complications compared to the non-obese cohort. CONCLUSIONS: Obese IBD hospitalizations had higher length of stay, total hospital charge, and complications compared to the non-obese cohort.
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spelling pubmed-93442442022-08-02 A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations Dahiya, Dushyant Singh Kichloo, Asim Wani, Farah Singh, Jagmeet Solanki, Dhanshree Shaka, Hafeez Intest Res Original Article BACKGROUND/AIMS: Proinflammatory cytokines released from adipocytes can influence the development, progression, and treatment of inflammatory bowel disease (IBD), and may be associated with worse clinical outcomes. METHODS: For 2016–2018, we analyzed data from the Nationwide Inpatient Sample to identify adult (≥18 years) hospitalizations with a primary discharge diagnosis of IBD. The study sample was divided based on the presence or absence of obesity. The primary outcomes included inpatient mortality, while the secondary outcomes consisted of system-based complications and disease implications on the United States healthcare system. RESULTS: We identified 282,005 hospitalizations of IBD from 2016 to 2018. Of these hospitalizations, 26,465 (9.4%) had a secondary diagnosis of obesity while 255,540 (90.6%) served as controls. IBD hospitalizations with obesity had a higher mean age (47.9 years vs. 45.2 years, P<0.001), middle age (range, 40–65 years) predominance (37.7% vs. 28.9%, P<0.001), female predominance (64.1% vs. 52.5%, P<0.001) and higher proportion of patients with comorbidities compared to the non-obese cohort. White predominance was observed in both subgroups. No difference in the odds of inpatient mortality was noted between the 2 subgroups; however, IBD hospitalizations with obesity had higher mean total hospital charge ($50,126 vs. $45,001, P<0.001), longer length of stay (5.5 days vs. 4.9 days, P<0.001) and higher proportion of complications compared to the non-obese cohort. CONCLUSIONS: Obese IBD hospitalizations had higher length of stay, total hospital charge, and complications compared to the non-obese cohort. Korean Association for the Study of Intestinal Diseases 2022-07 2021-05-21 /pmc/articles/PMC9344244/ /pubmed/34011019 http://dx.doi.org/10.5217/ir.2021.00046 Text en © Copyright 2022. Korean Association for the Study of Intestinal Diseases. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dahiya, Dushyant Singh
Kichloo, Asim
Wani, Farah
Singh, Jagmeet
Solanki, Dhanshree
Shaka, Hafeez
A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
title A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
title_full A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
title_fullStr A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
title_full_unstemmed A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
title_short A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
title_sort nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344244/
https://www.ncbi.nlm.nih.gov/pubmed/34011019
http://dx.doi.org/10.5217/ir.2021.00046
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