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EML4-ALK fusion gene in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule-associated protei...

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Detalles Bibliográficos
Autores principales: Lei, Yu, Lei, Yan, Shi, Xiang, Wang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344266/
https://www.ncbi.nlm.nih.gov/pubmed/35928804
http://dx.doi.org/10.3892/ol.2022.13397
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author Lei, Yu
Lei, Yan
Shi, Xiang
Wang, Jingjing
author_facet Lei, Yu
Lei, Yan
Shi, Xiang
Wang, Jingjing
author_sort Lei, Yu
collection PubMed
description Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene is one of the most important pathogenic driver genes of NSCLC discovered thus far. Four generations of targeted drugs for EML4-ALK have been developed, with patients benefiting significantly from these drugs. Therefore, EML4-ALK has become a research hotspot in NSCLC. The aim of the present study is to introduce the current research progress of EML4-ALK and its association with NSCLC.
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spelling pubmed-93442662022-08-03 EML4-ALK fusion gene in non-small cell lung cancer Lei, Yu Lei, Yan Shi, Xiang Wang, Jingjing Oncol Lett Review Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene is one of the most important pathogenic driver genes of NSCLC discovered thus far. Four generations of targeted drugs for EML4-ALK have been developed, with patients benefiting significantly from these drugs. Therefore, EML4-ALK has become a research hotspot in NSCLC. The aim of the present study is to introduce the current research progress of EML4-ALK and its association with NSCLC. D.A. Spandidos 2022-06-24 /pmc/articles/PMC9344266/ /pubmed/35928804 http://dx.doi.org/10.3892/ol.2022.13397 Text en Copyright: © Lei et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Lei, Yu
Lei, Yan
Shi, Xiang
Wang, Jingjing
EML4-ALK fusion gene in non-small cell lung cancer
title EML4-ALK fusion gene in non-small cell lung cancer
title_full EML4-ALK fusion gene in non-small cell lung cancer
title_fullStr EML4-ALK fusion gene in non-small cell lung cancer
title_full_unstemmed EML4-ALK fusion gene in non-small cell lung cancer
title_short EML4-ALK fusion gene in non-small cell lung cancer
title_sort eml4-alk fusion gene in non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344266/
https://www.ncbi.nlm.nih.gov/pubmed/35928804
http://dx.doi.org/10.3892/ol.2022.13397
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