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EML4-ALK fusion gene in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule-associated protei...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344266/ https://www.ncbi.nlm.nih.gov/pubmed/35928804 http://dx.doi.org/10.3892/ol.2022.13397 |
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author | Lei, Yu Lei, Yan Shi, Xiang Wang, Jingjing |
author_facet | Lei, Yu Lei, Yan Shi, Xiang Wang, Jingjing |
author_sort | Lei, Yu |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene is one of the most important pathogenic driver genes of NSCLC discovered thus far. Four generations of targeted drugs for EML4-ALK have been developed, with patients benefiting significantly from these drugs. Therefore, EML4-ALK has become a research hotspot in NSCLC. The aim of the present study is to introduce the current research progress of EML4-ALK and its association with NSCLC. |
format | Online Article Text |
id | pubmed-9344266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-93442662022-08-03 EML4-ALK fusion gene in non-small cell lung cancer Lei, Yu Lei, Yan Shi, Xiang Wang, Jingjing Oncol Lett Review Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene is one of the most important pathogenic driver genes of NSCLC discovered thus far. Four generations of targeted drugs for EML4-ALK have been developed, with patients benefiting significantly from these drugs. Therefore, EML4-ALK has become a research hotspot in NSCLC. The aim of the present study is to introduce the current research progress of EML4-ALK and its association with NSCLC. D.A. Spandidos 2022-06-24 /pmc/articles/PMC9344266/ /pubmed/35928804 http://dx.doi.org/10.3892/ol.2022.13397 Text en Copyright: © Lei et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Lei, Yu Lei, Yan Shi, Xiang Wang, Jingjing EML4-ALK fusion gene in non-small cell lung cancer |
title | EML4-ALK fusion gene in non-small cell lung cancer |
title_full | EML4-ALK fusion gene in non-small cell lung cancer |
title_fullStr | EML4-ALK fusion gene in non-small cell lung cancer |
title_full_unstemmed | EML4-ALK fusion gene in non-small cell lung cancer |
title_short | EML4-ALK fusion gene in non-small cell lung cancer |
title_sort | eml4-alk fusion gene in non-small cell lung cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344266/ https://www.ncbi.nlm.nih.gov/pubmed/35928804 http://dx.doi.org/10.3892/ol.2022.13397 |
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