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Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted

A novel series of 6-iodo-2-methylquinazolin-4-(3H)-one derivatives, 3a–n, were synthesized and evaluated for their in vitro cytotoxic activity. Compounds 3a, 3b, 3d, 3e, and 3h showed remarkable cytotoxic activity on specific human cancer cell lines when compared to the anti-cancer drug, paclitaxel....

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Detalles Bibliográficos
Autores principales:	Pérez-Fehrmann, Marcia, Kesternich, Víctor, Puelles, Arturo, Quezada, Víctor, Salazar, Fernanda, Christen, Philippe, Castillo, Jonathan, Cárcamo, Juan Guillermo, Castro-Alvarez, Alejandro, Nelson, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344282/ https://www.ncbi.nlm.nih.gov/pubmed/35975048 http://dx.doi.org/10.1039/d2ra03684c

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