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Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease
BACKGROUND AND AIM: Non‐alcoholic fatty liver disease (NAFLD) is common in the United States and China. We compared prevalence of metabolic syndrome (MS), hepatic steatosis and fibrosis, and quantity and quality of body fat between American versus Chinese patients with NAFLD. METHODS: NAFLD patients...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344583/ https://www.ncbi.nlm.nih.gov/pubmed/35928698 http://dx.doi.org/10.1002/jgh3.12756 |
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author | Zhang, Wei Su, Grace L Sravanthi, Kaza Huang, Rui Wang, Yi Rao, Huiying Wei, Lai Lok, Anna S |
author_facet | Zhang, Wei Su, Grace L Sravanthi, Kaza Huang, Rui Wang, Yi Rao, Huiying Wei, Lai Lok, Anna S |
author_sort | Zhang, Wei |
collection | PubMed |
description | BACKGROUND AND AIM: Non‐alcoholic fatty liver disease (NAFLD) is common in the United States and China. We compared prevalence of metabolic syndrome (MS), hepatic steatosis and fibrosis, and quantity and quality of body fat between American versus Chinese patients with NAFLD. METHODS: NAFLD patients were prospectively recruited from the University of Michigan Health System (UMHS) in the United States and Peking University Health Sciences Center (PUHSC) in China. All patients had baseline computed tomography (CT), laboratory tests and Fibroscan® controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Comparisons were made for overall cohorts and matched cohorts (matched for sex, age, and body mass index [BMI] category). Logistic regression was performed to identify independent predictors of moderate and severe steatosis and lack of advanced fibrosis. RESULTS: One‐hundred and one American and One‐hundred and sixty Chinese patients were included. UMHS patients were older, with higher prevalence of MS, had higher LSM and CAP scores, and more fat in liver, visceral, subcutaneous, and muscle compartments than PUHSC patients. Differences in LSM, visceral fat Hounsfield unit, and subcutaneous fat area (SFA) persisted in the matched cohort. NAFLD patients with MS had significantly higher LSM, and more fat in liver, visceral, subcutaneous and muscle compartments than those without. Moderate or severe steatosis was independently associated with MS, visceral fat quality, and SFA, while the absence of advanced fibrosis was associated with Asian race and not having MS. CONCLUSION: American patients with NAFLD had more liver fibrosis than Chinese patients despite having better quality visceral fat and after matching for age, sex, and BMI category. |
format | Online Article Text |
id | pubmed-9344583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-93445832022-08-03 Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease Zhang, Wei Su, Grace L Sravanthi, Kaza Huang, Rui Wang, Yi Rao, Huiying Wei, Lai Lok, Anna S JGH Open Leading Article BACKGROUND AND AIM: Non‐alcoholic fatty liver disease (NAFLD) is common in the United States and China. We compared prevalence of metabolic syndrome (MS), hepatic steatosis and fibrosis, and quantity and quality of body fat between American versus Chinese patients with NAFLD. METHODS: NAFLD patients were prospectively recruited from the University of Michigan Health System (UMHS) in the United States and Peking University Health Sciences Center (PUHSC) in China. All patients had baseline computed tomography (CT), laboratory tests and Fibroscan® controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Comparisons were made for overall cohorts and matched cohorts (matched for sex, age, and body mass index [BMI] category). Logistic regression was performed to identify independent predictors of moderate and severe steatosis and lack of advanced fibrosis. RESULTS: One‐hundred and one American and One‐hundred and sixty Chinese patients were included. UMHS patients were older, with higher prevalence of MS, had higher LSM and CAP scores, and more fat in liver, visceral, subcutaneous, and muscle compartments than PUHSC patients. Differences in LSM, visceral fat Hounsfield unit, and subcutaneous fat area (SFA) persisted in the matched cohort. NAFLD patients with MS had significantly higher LSM, and more fat in liver, visceral, subcutaneous and muscle compartments than those without. Moderate or severe steatosis was independently associated with MS, visceral fat quality, and SFA, while the absence of advanced fibrosis was associated with Asian race and not having MS. CONCLUSION: American patients with NAFLD had more liver fibrosis than Chinese patients despite having better quality visceral fat and after matching for age, sex, and BMI category. Wiley Publishing Asia Pty Ltd 2022-05-23 /pmc/articles/PMC9344583/ /pubmed/35928698 http://dx.doi.org/10.1002/jgh3.12756 Text en © 2022 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Leading Article Zhang, Wei Su, Grace L Sravanthi, Kaza Huang, Rui Wang, Yi Rao, Huiying Wei, Lai Lok, Anna S Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease |
title | Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease |
title_full | Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease |
title_fullStr | Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease |
title_full_unstemmed | Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease |
title_short | Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease |
title_sort | metabolic abnormalities, liver and body fat in american versus chinese patients with non‐alcoholic fatty liver disease |
topic | Leading Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344583/ https://www.ncbi.nlm.nih.gov/pubmed/35928698 http://dx.doi.org/10.1002/jgh3.12756 |
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