Management of dyslipidemia after allogeneic hematopoietic stem cell transplantation

Dyslipidemia is one of the complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and it is often underestimated and undertreated. Dyslipidemia in allo-HSCT recipients has been confirmed to be associated with endocrine dysfunction, acute and chronic graft-versus-host dis...

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Detalles Bibliográficos
Autores principales: Lu, Yingxue, Ma, Xiaojing, Pan, Jie, Ma, Rongqiang, Jiang, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344644/
https://www.ncbi.nlm.nih.gov/pubmed/35918766
http://dx.doi.org/10.1186/s12944-022-01665-3
Descripción
Sumario:Dyslipidemia is one of the complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and it is often underestimated and undertreated. Dyslipidemia in allo-HSCT recipients has been confirmed to be associated with endocrine dysfunction, acute and chronic graft-versus-host disease (aGVHD and cGVHD), immunosuppressive agent application, etc. However, few studies have illustrated the accurate molecular signaling pathways involved in dyslipidemia, and there are no standard guidelines for dyslipidemia management after HSCT. This review will discuss the pathogenesis of dyslipidemia, especially the association with aGVHD and/or cGVHD. Comprehensive treatment methods for dyslipidemia after HSCT will also be summarized. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-022-01665-3.

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