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Multifunctional fish gelatin hydrogel inverse opal films for wound healing
BACKGROUND: Wound healing has become a worldwide healthcare issue. Attempts in the area focus on developing patches with the capabilities of avoiding wound infection, promoting tissue remolding, and reporting treatment status that are of great value for wound treatment. RESULTS: In this paper, we pr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344764/ https://www.ncbi.nlm.nih.gov/pubmed/35918727 http://dx.doi.org/10.1186/s12951-022-01564-w |
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author | Cao, Xinyue Zhang, Zhuohao Sun, Lingyu Luo, Zhiqiang Zhao, Yuanjin |
author_facet | Cao, Xinyue Zhang, Zhuohao Sun, Lingyu Luo, Zhiqiang Zhao, Yuanjin |
author_sort | Cao, Xinyue |
collection | PubMed |
description | BACKGROUND: Wound healing has become a worldwide healthcare issue. Attempts in the area focus on developing patches with the capabilities of avoiding wound infection, promoting tissue remolding, and reporting treatment status that are of great value for wound treatment. RESULTS: In this paper, we present a novel inverse opal film (IOF) patch based on a photo-crosslinking fish gelatin hydrogel with the desired features for wound healing and dynamic monitoring. The film with vibrant structure colors was constructed by using the mixture of fish gelatin methacryloyl, chitosan, and polyacrylic acid (PAA) to replicate colloidal crystal templates. As the structures of these natural biomolecules are well-retained during the fabrication, the resultant IOF was with brilliant biocompatibility, low immunogenicity, antibacterial property, as well as with the functions of promoting tissue growth and wound healing. In addition, the IOF presented interconnected nanopores and high specific surface areas for vascular endothelial growth factor loading, which could further improve its angiogenesis capability. More attractively, as the pH-responsive PAA was incorporated, the IOF patch could report the wound healing status through its real-time structural colors or reflectance spectra. CONCLUSIONS: These features implied the practical value of the multifunctional fish gelatin hydrogel IOFs in clinical wound management. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01564-w. |
format | Online Article Text |
id | pubmed-9344764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93447642022-08-03 Multifunctional fish gelatin hydrogel inverse opal films for wound healing Cao, Xinyue Zhang, Zhuohao Sun, Lingyu Luo, Zhiqiang Zhao, Yuanjin J Nanobiotechnology Research BACKGROUND: Wound healing has become a worldwide healthcare issue. Attempts in the area focus on developing patches with the capabilities of avoiding wound infection, promoting tissue remolding, and reporting treatment status that are of great value for wound treatment. RESULTS: In this paper, we present a novel inverse opal film (IOF) patch based on a photo-crosslinking fish gelatin hydrogel with the desired features for wound healing and dynamic monitoring. The film with vibrant structure colors was constructed by using the mixture of fish gelatin methacryloyl, chitosan, and polyacrylic acid (PAA) to replicate colloidal crystal templates. As the structures of these natural biomolecules are well-retained during the fabrication, the resultant IOF was with brilliant biocompatibility, low immunogenicity, antibacterial property, as well as with the functions of promoting tissue growth and wound healing. In addition, the IOF presented interconnected nanopores and high specific surface areas for vascular endothelial growth factor loading, which could further improve its angiogenesis capability. More attractively, as the pH-responsive PAA was incorporated, the IOF patch could report the wound healing status through its real-time structural colors or reflectance spectra. CONCLUSIONS: These features implied the practical value of the multifunctional fish gelatin hydrogel IOFs in clinical wound management. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01564-w. BioMed Central 2022-08-02 /pmc/articles/PMC9344764/ /pubmed/35918727 http://dx.doi.org/10.1186/s12951-022-01564-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Cao, Xinyue Zhang, Zhuohao Sun, Lingyu Luo, Zhiqiang Zhao, Yuanjin Multifunctional fish gelatin hydrogel inverse opal films for wound healing |
title | Multifunctional fish gelatin hydrogel inverse opal films for wound healing |
title_full | Multifunctional fish gelatin hydrogel inverse opal films for wound healing |
title_fullStr | Multifunctional fish gelatin hydrogel inverse opal films for wound healing |
title_full_unstemmed | Multifunctional fish gelatin hydrogel inverse opal films for wound healing |
title_short | Multifunctional fish gelatin hydrogel inverse opal films for wound healing |
title_sort | multifunctional fish gelatin hydrogel inverse opal films for wound healing |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344764/ https://www.ncbi.nlm.nih.gov/pubmed/35918727 http://dx.doi.org/10.1186/s12951-022-01564-w |
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