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Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction

Correct chromosome segregation in mitosis relies on chromosome biorientation, in which sister kinetochores attach to microtubules from opposite spindle poles prior to segregation. To establish biorientation, aberrant kinetochore–microtubule interactions must be resolved through the error correction...

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Detalles Bibliográficos
Autores principales: Doodhi, Harinath, Tanaka, Tomoyuki U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344824/
https://www.ncbi.nlm.nih.gov/pubmed/35261042
http://dx.doi.org/10.1002/bies.202100246
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author Doodhi, Harinath
Tanaka, Tomoyuki U.
author_facet Doodhi, Harinath
Tanaka, Tomoyuki U.
author_sort Doodhi, Harinath
collection PubMed
description Correct chromosome segregation in mitosis relies on chromosome biorientation, in which sister kinetochores attach to microtubules from opposite spindle poles prior to segregation. To establish biorientation, aberrant kinetochore–microtubule interactions must be resolved through the error correction process. During error correction, kinetochore–microtubule interactions are exchanged (swapped) if aberrant, but the exchange must stop when biorientation is established. In this article, we discuss recent findings in budding yeast, which have revealed fundamental molecular mechanisms promoting this “swap and stop” process for error correction. Where relevant, we also compare the findings in budding yeast with mechanisms in higher eukaryotes. Evidence suggests that Aurora B kinase differentially regulates kinetochore attachments to the microtubule end and its lateral side and switches relative strength of the two kinetochore–microtubule attachment modes, which drives the exchange of kinetochore–microtubule interactions to resolve aberrant interactions. However, Aurora B kinase, recruited to centromeres and inner kinetochores, cannot reach its targets at kinetochore–microtubule interface when tension causes kinetochore stretching, which stops the kinetochore–microtubule exchange once biorientation is established.
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spelling pubmed-93448242022-08-04 Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction Doodhi, Harinath Tanaka, Tomoyuki U. Bioessays PROBLEMS & PARADIGMS Correct chromosome segregation in mitosis relies on chromosome biorientation, in which sister kinetochores attach to microtubules from opposite spindle poles prior to segregation. To establish biorientation, aberrant kinetochore–microtubule interactions must be resolved through the error correction process. During error correction, kinetochore–microtubule interactions are exchanged (swapped) if aberrant, but the exchange must stop when biorientation is established. In this article, we discuss recent findings in budding yeast, which have revealed fundamental molecular mechanisms promoting this “swap and stop” process for error correction. Where relevant, we also compare the findings in budding yeast with mechanisms in higher eukaryotes. Evidence suggests that Aurora B kinase differentially regulates kinetochore attachments to the microtubule end and its lateral side and switches relative strength of the two kinetochore–microtubule attachment modes, which drives the exchange of kinetochore–microtubule interactions to resolve aberrant interactions. However, Aurora B kinase, recruited to centromeres and inner kinetochores, cannot reach its targets at kinetochore–microtubule interface when tension causes kinetochore stretching, which stops the kinetochore–microtubule exchange once biorientation is established. John Wiley and Sons Inc. 2022-03-08 2022-05 /pmc/articles/PMC9344824/ /pubmed/35261042 http://dx.doi.org/10.1002/bies.202100246 Text en © 2022 The Authors. BioEssays published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle PROBLEMS & PARADIGMS
Doodhi, Harinath
Tanaka, Tomoyuki U.
Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction
title Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction
title_full Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction
title_fullStr Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction
title_full_unstemmed Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction
title_short Swap and stop – Kinetochores play error correction with microtubules: Mechanisms of kinetochore–microtubule error correction
title_sort swap and stop – kinetochores play error correction with microtubules: mechanisms of kinetochore–microtubule error correction
topic PROBLEMS & PARADIGMS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344824/
https://www.ncbi.nlm.nih.gov/pubmed/35261042
http://dx.doi.org/10.1002/bies.202100246
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