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Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective
Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in hematological malignancies. However, the clinical development of immunotoxins is also faced with many challenges like anti-drug antibodies and dose-limiting toxicity issues. Such a poor efficacy or safety ratio is also...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344849/ https://www.ncbi.nlm.nih.gov/pubmed/35928456 http://dx.doi.org/10.1093/abt/tbac014 |