Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase

[Image: see text] Taking advantage of the uniquely constricted active site of SARS-CoV-2 Nsp14 methyltransferase, we have designed bisubstrate inhibitors interacting with the SAM and RNA substrate binding pockets. Our efforts have led to nanomolar inhibitors including compounds 3 and 10. As a protot...

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Detalles Bibliográficos
Autores principales: Jung, Eunkyung, Soto-Acosta, Ruben, Xie, Jiashu, Wilson, Daniel J., Dreis, Christine D., Majima, Ryuichi, Edwards, Tiffany C., Geraghty, Robert J., Chen, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344893/
https://www.ncbi.nlm.nih.gov/pubmed/36097498
http://dx.doi.org/10.1021/acsmedchemlett.2c00265

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