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Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy

The objective of the study was to characterize the pattern of cognitive dysfunction in patients with multiple system atrophy (MSA) applying a standardized neuropsychological assessment. A total of 20 patients with the diagnosis of probable or possible MSA were enrolled for neuropsychological assessm...

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Autores principales: Maass, Fabian, Hermann, Peter, Varges, Daniela, Nuhn, Sabine, van Riesen, Christoph, Jamous, Ala, Focke, Niels K., Hewitt, Manuel, Leha, Andreas, Bähr, Mathias, Zerr, Inga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344909/
https://www.ncbi.nlm.nih.gov/pubmed/35928131
http://dx.doi.org/10.3389/fneur.2022.881369
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author Maass, Fabian
Hermann, Peter
Varges, Daniela
Nuhn, Sabine
van Riesen, Christoph
Jamous, Ala
Focke, Niels K.
Hewitt, Manuel
Leha, Andreas
Bähr, Mathias
Zerr, Inga
author_facet Maass, Fabian
Hermann, Peter
Varges, Daniela
Nuhn, Sabine
van Riesen, Christoph
Jamous, Ala
Focke, Niels K.
Hewitt, Manuel
Leha, Andreas
Bähr, Mathias
Zerr, Inga
author_sort Maass, Fabian
collection PubMed
description The objective of the study was to characterize the pattern of cognitive dysfunction in patients with multiple system atrophy (MSA) applying a standardized neuropsychological assessment. A total of 20 patients with the diagnosis of probable or possible MSA were enrolled for neuropsychological assessment applying the CERAD plus battery. All patients were tested at baseline and 14/20 patients received additional follow-up assessments (median follow-up of 24 months). Additionally, relationship between cortical thickness values/subcortical gray matter volumes and CERAD subitems was evaluated at baseline in a subgroup of 13/20 patients. Trail Making Test (TMT) was the most sensitive CERAD item at baseline with abnormal performance (z-score < −1.28) in one or both pathological TMT items (TMT-A, TMT-B) in 60% of patients with MSA. Additionally, there was a significant inverse correlation between the volume of the left and the right accumbens area and the TMT A item after adjusting for age (left side: p = 0.0009; right side p = 0.003). Comparing both subtypes, patients with MSA-C had significant lower values in phonemic verbal fluency (p = 0.04) and a trend for lower values in semantic verbal fluency (p = 0.06) compared to MSA-P. Additionally, patients with MSA-C showed significantly worse performance in the TMT-B task (p = 0.04) and a trend for worse performance in the TMT-A task (p = 0.06). Concerning longitudinal follow-up, a significant worsening in the TMT-B (p = 0.03) can be reported in MSA. In conclusion, frontal-executive dysfunction presents the hallmark of cognitive impairment in MSA.
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spelling pubmed-93449092022-08-03 Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy Maass, Fabian Hermann, Peter Varges, Daniela Nuhn, Sabine van Riesen, Christoph Jamous, Ala Focke, Niels K. Hewitt, Manuel Leha, Andreas Bähr, Mathias Zerr, Inga Front Neurol Neurology The objective of the study was to characterize the pattern of cognitive dysfunction in patients with multiple system atrophy (MSA) applying a standardized neuropsychological assessment. A total of 20 patients with the diagnosis of probable or possible MSA were enrolled for neuropsychological assessment applying the CERAD plus battery. All patients were tested at baseline and 14/20 patients received additional follow-up assessments (median follow-up of 24 months). Additionally, relationship between cortical thickness values/subcortical gray matter volumes and CERAD subitems was evaluated at baseline in a subgroup of 13/20 patients. Trail Making Test (TMT) was the most sensitive CERAD item at baseline with abnormal performance (z-score < −1.28) in one or both pathological TMT items (TMT-A, TMT-B) in 60% of patients with MSA. Additionally, there was a significant inverse correlation between the volume of the left and the right accumbens area and the TMT A item after adjusting for age (left side: p = 0.0009; right side p = 0.003). Comparing both subtypes, patients with MSA-C had significant lower values in phonemic verbal fluency (p = 0.04) and a trend for lower values in semantic verbal fluency (p = 0.06) compared to MSA-P. Additionally, patients with MSA-C showed significantly worse performance in the TMT-B task (p = 0.04) and a trend for worse performance in the TMT-A task (p = 0.06). Concerning longitudinal follow-up, a significant worsening in the TMT-B (p = 0.03) can be reported in MSA. In conclusion, frontal-executive dysfunction presents the hallmark of cognitive impairment in MSA. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9344909/ /pubmed/35928131 http://dx.doi.org/10.3389/fneur.2022.881369 Text en Copyright © 2022 Maass, Hermann, Varges, Nuhn, van Riesen, Jamous, Focke, Hewitt, Leha, Bähr and Zerr. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Maass, Fabian
Hermann, Peter
Varges, Daniela
Nuhn, Sabine
van Riesen, Christoph
Jamous, Ala
Focke, Niels K.
Hewitt, Manuel
Leha, Andreas
Bähr, Mathias
Zerr, Inga
Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy
title Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy
title_full Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy
title_fullStr Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy
title_full_unstemmed Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy
title_short Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy
title_sort prospective cerad neuropsychological assessment in patients with multiple system atrophy
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344909/
https://www.ncbi.nlm.nih.gov/pubmed/35928131
http://dx.doi.org/10.3389/fneur.2022.881369
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