Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy

Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not prac...

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Autores principales: Abravan, Azadeh, Price, Gareth, Banfill, Kathryn, Marchant, Tom, Craddock, Matthew, Wood, Joe, Aznar, Marianne C., McWilliam, Alan, van Herk, Marcel, Faivre-Finn, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344971/
https://www.ncbi.nlm.nih.gov/pubmed/35928875
http://dx.doi.org/10.3389/fonc.2022.934369
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author Abravan, Azadeh
Price, Gareth
Banfill, Kathryn
Marchant, Tom
Craddock, Matthew
Wood, Joe
Aznar, Marianne C.
McWilliam, Alan
van Herk, Marcel
Faivre-Finn, Corinne
author_facet Abravan, Azadeh
Price, Gareth
Banfill, Kathryn
Marchant, Tom
Craddock, Matthew
Wood, Joe
Aznar, Marianne C.
McWilliam, Alan
van Herk, Marcel
Faivre-Finn, Corinne
author_sort Abravan, Azadeh
collection PubMed
description Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not practical in this field. This article is a narrative review of the literature using RWD to study RIHD in patients with lung cancer following radiotherapy, summarizing heart dosimetric factors associated with outcome, strength, and limitations of the RWD studies, and how RWD can be used to assess a change to cardiac dose constraints.
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spelling pubmed-93449712022-08-03 Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy Abravan, Azadeh Price, Gareth Banfill, Kathryn Marchant, Tom Craddock, Matthew Wood, Joe Aznar, Marianne C. McWilliam, Alan van Herk, Marcel Faivre-Finn, Corinne Front Oncol Oncology Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not practical in this field. This article is a narrative review of the literature using RWD to study RIHD in patients with lung cancer following radiotherapy, summarizing heart dosimetric factors associated with outcome, strength, and limitations of the RWD studies, and how RWD can be used to assess a change to cardiac dose constraints. Frontiers Media S.A. 2022-07-19 /pmc/articles/PMC9344971/ /pubmed/35928875 http://dx.doi.org/10.3389/fonc.2022.934369 Text en Copyright © 2022 Abravan, Price, Banfill, Marchant, Craddock, Wood, Aznar, McWilliam, van Herk and Faivre-Finn https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Abravan, Azadeh
Price, Gareth
Banfill, Kathryn
Marchant, Tom
Craddock, Matthew
Wood, Joe
Aznar, Marianne C.
McWilliam, Alan
van Herk, Marcel
Faivre-Finn, Corinne
Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy
title Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy
title_full Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy
title_fullStr Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy
title_full_unstemmed Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy
title_short Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy
title_sort role of real-world data in assessing cardiac toxicity after lung cancer radiotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344971/
https://www.ncbi.nlm.nih.gov/pubmed/35928875
http://dx.doi.org/10.3389/fonc.2022.934369
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