Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2

We used human semi-synthetic phage antibody gene libraries to select anti-SARS-CoV-2 RBD scFv antibody fragment and subsequent characterization of this novel tetravalent monoclonal antibody targeting conformational epitopes in the receptor binding domain of SARS-CoV-2. Binding studies suggest that I...

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Detalles Bibliográficos
Autores principales: Garg, Sonal, Raj, Nisha, Lukose, Asha, Jamwal, Deepti, Parray, Hilal Ahmed, Kumar, Sandeep, Dhyani, Samridhi, Jakhar, Kamini, Sonar, Sudipta, Tiwari, Mahima, Reema, Mani, Shailendra, Bhattacharyya, Sankar, Sharma, Chandresh, Shrivastava, Tripti, Kumar, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345016/
https://www.ncbi.nlm.nih.gov/pubmed/35928502
http://dx.doi.org/10.1007/s13205-022-03272-6

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