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Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review

BACKGROUND: Coronavirus disease 2019 (COVID-19) is responsible for a wide variety of multi-system clinical features. Facial nerve palsy (FNP) is identified as one of the neurological complications of the virus. This work aims to systematically review the clinical picture, laboratory/imaging findings...

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Autores principales: Turki, Aya, Abbas, Kirellos Said, Makram, Abdelrahman M, Elfert, Mostafa, Elmarabea, Mahmoud, El-Shahat, Nahla Ahmed, Abdalshafy, Hassan, Sampong, Akua, Chintalapati, Sirisha, Huy, Nguyen Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345018/
https://www.ncbi.nlm.nih.gov/pubmed/35917018
http://dx.doi.org/10.1007/s13760-022-02026-8
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author Turki, Aya
Abbas, Kirellos Said
Makram, Abdelrahman M
Elfert, Mostafa
Elmarabea, Mahmoud
El-Shahat, Nahla Ahmed
Abdalshafy, Hassan
Sampong, Akua
Chintalapati, Sirisha
Huy, Nguyen Tien
author_facet Turki, Aya
Abbas, Kirellos Said
Makram, Abdelrahman M
Elfert, Mostafa
Elmarabea, Mahmoud
El-Shahat, Nahla Ahmed
Abdalshafy, Hassan
Sampong, Akua
Chintalapati, Sirisha
Huy, Nguyen Tien
author_sort Turki, Aya
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) is responsible for a wide variety of multi-system clinical features. Facial nerve palsy (FNP) is identified as one of the neurological complications of the virus. This work aims to systematically review the clinical picture, laboratory/imaging findings, treatment options, and prognostic factors of FNP in COVID-19 patients. METHODS: Using six online databases, a search was conducted to include all articles with patients infected with COVID-19 and presenting with unilateral or bilateral FNP. Screening for eligibility and data extraction were done by three and four independent reviewers, respectively. Descriptive analyses and data visualizations were done using Google Sheets. Survival analysis and Kaplan–Meier plotting were done by R software. RESULTS: The data from 22 studies included 32 patients who were infected with COVID-19 and presented with clinical features of FNP. Fourteen patients were male while 18 were female. FNP affected 29 patients unilaterally and 3 patients bilaterally. The imaging findings confirmed that complications of FNP were COVID-19 related. Additionally, antivirals combined with steroids had the lowest median time (21, IQR = 8) to clinical improvement compared to steroid-only (30, IQR = 15) and antiviral-only (33, IQR = 3.5) treatments. CONCLUSION: This study has shown a potential correlation between the increased incidence of FNP and COVID-19. We have also found that combining antivirals with steroids may have better outcomes in patients with FNP and COVID-19 although the evidence to support this claim is not strong enough. Further studies are required to assess the extent of linkage between the two conditions and how to properly manage FNP when encountered in COVID-19 patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13760-022-02026-8.
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spelling pubmed-93450182022-08-03 Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review Turki, Aya Abbas, Kirellos Said Makram, Abdelrahman M Elfert, Mostafa Elmarabea, Mahmoud El-Shahat, Nahla Ahmed Abdalshafy, Hassan Sampong, Akua Chintalapati, Sirisha Huy, Nguyen Tien Acta Neurol Belg Review Article BACKGROUND: Coronavirus disease 2019 (COVID-19) is responsible for a wide variety of multi-system clinical features. Facial nerve palsy (FNP) is identified as one of the neurological complications of the virus. This work aims to systematically review the clinical picture, laboratory/imaging findings, treatment options, and prognostic factors of FNP in COVID-19 patients. METHODS: Using six online databases, a search was conducted to include all articles with patients infected with COVID-19 and presenting with unilateral or bilateral FNP. Screening for eligibility and data extraction were done by three and four independent reviewers, respectively. Descriptive analyses and data visualizations were done using Google Sheets. Survival analysis and Kaplan–Meier plotting were done by R software. RESULTS: The data from 22 studies included 32 patients who were infected with COVID-19 and presented with clinical features of FNP. Fourteen patients were male while 18 were female. FNP affected 29 patients unilaterally and 3 patients bilaterally. The imaging findings confirmed that complications of FNP were COVID-19 related. Additionally, antivirals combined with steroids had the lowest median time (21, IQR = 8) to clinical improvement compared to steroid-only (30, IQR = 15) and antiviral-only (33, IQR = 3.5) treatments. CONCLUSION: This study has shown a potential correlation between the increased incidence of FNP and COVID-19. We have also found that combining antivirals with steroids may have better outcomes in patients with FNP and COVID-19 although the evidence to support this claim is not strong enough. Further studies are required to assess the extent of linkage between the two conditions and how to properly manage FNP when encountered in COVID-19 patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13760-022-02026-8. Springer International Publishing 2022-08-02 2022 /pmc/articles/PMC9345018/ /pubmed/35917018 http://dx.doi.org/10.1007/s13760-022-02026-8 Text en © The Author(s) under exclusive licence to Belgian Neurological Society 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Turki, Aya
Abbas, Kirellos Said
Makram, Abdelrahman M
Elfert, Mostafa
Elmarabea, Mahmoud
El-Shahat, Nahla Ahmed
Abdalshafy, Hassan
Sampong, Akua
Chintalapati, Sirisha
Huy, Nguyen Tien
Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review
title Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review
title_full Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review
title_fullStr Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review
title_full_unstemmed Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review
title_short Epidemiology, clinical features, and treatment modalities of facial nerve palsy in COVID-19 patients: a systematic review
title_sort epidemiology, clinical features, and treatment modalities of facial nerve palsy in covid-19 patients: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345018/
https://www.ncbi.nlm.nih.gov/pubmed/35917018
http://dx.doi.org/10.1007/s13760-022-02026-8
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