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A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, a...

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Autores principales: Margiana, Ria, Pakpahan, Cennikon, Pangestu, Mulyoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345263/
https://www.ncbi.nlm.nih.gov/pubmed/35967975
http://dx.doi.org/10.12688/f1000research.110510.2
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author Margiana, Ria
Pakpahan, Cennikon
Pangestu, Mulyoto
author_facet Margiana, Ria
Pakpahan, Cennikon
Pangestu, Mulyoto
author_sort Margiana, Ria
collection PubMed
description Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care.
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spelling pubmed-93452632022-08-11 A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application Margiana, Ria Pakpahan, Cennikon Pangestu, Mulyoto F1000Res Systematic Review Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care. F1000 Research Limited 2022-07-27 /pmc/articles/PMC9345263/ /pubmed/35967975 http://dx.doi.org/10.12688/f1000research.110510.2 Text en Copyright: © 2022 Margiana R et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Systematic Review
Margiana, Ria
Pakpahan, Cennikon
Pangestu, Mulyoto
A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
title A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
title_full A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
title_fullStr A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
title_full_unstemmed A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
title_short A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
title_sort systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: from basic to clinical application
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345263/
https://www.ncbi.nlm.nih.gov/pubmed/35967975
http://dx.doi.org/10.12688/f1000research.110510.2
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