A mini-review on quantification of atherosclerosis in hypercholesterolemic mice

Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. En face analyses of the aorta and cross-sections of the aortic root are the two common modes for quan...

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Autores principales: Chen, Hui, Howatt, Deborah A., Franklin, Michael K., Amioka, Naofumi, Sawada, Hisashi, Daugherty, Alan, Lu, Hong S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345319/
https://www.ncbi.nlm.nih.gov/pubmed/35925518
http://dx.doi.org/10.36922/gtm.v1i1.76
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author Chen, Hui
Howatt, Deborah A.
Franklin, Michael K.
Amioka, Naofumi
Sawada, Hisashi
Daugherty, Alan
Lu, Hong S.
author_facet Chen, Hui
Howatt, Deborah A.
Franklin, Michael K.
Amioka, Naofumi
Sawada, Hisashi
Daugherty, Alan
Lu, Hong S.
author_sort Chen, Hui
collection PubMed
description Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. En face analyses of the aorta and cross-sections of the aortic root are the two common modes for quantifying the severity of atherosclerosis in mice. This mini-review introduces these two methods, discusses their pros and cons, and provides suggestions to optimize the quantification of atherosclerosis, thereby enhancing rigor and reproducibility in preclinical research.
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spelling pubmed-93453192022-08-02 A mini-review on quantification of atherosclerosis in hypercholesterolemic mice Chen, Hui Howatt, Deborah A. Franklin, Michael K. Amioka, Naofumi Sawada, Hisashi Daugherty, Alan Lu, Hong S. Glob Transl Med Article Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. En face analyses of the aorta and cross-sections of the aortic root are the two common modes for quantifying the severity of atherosclerosis in mice. This mini-review introduces these two methods, discusses their pros and cons, and provides suggestions to optimize the quantification of atherosclerosis, thereby enhancing rigor and reproducibility in preclinical research. 2022 2022-06-14 /pmc/articles/PMC9345319/ /pubmed/35925518 http://dx.doi.org/10.36922/gtm.v1i1.76 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Chen, Hui
Howatt, Deborah A.
Franklin, Michael K.
Amioka, Naofumi
Sawada, Hisashi
Daugherty, Alan
Lu, Hong S.
A mini-review on quantification of atherosclerosis in hypercholesterolemic mice
title A mini-review on quantification of atherosclerosis in hypercholesterolemic mice
title_full A mini-review on quantification of atherosclerosis in hypercholesterolemic mice
title_fullStr A mini-review on quantification of atherosclerosis in hypercholesterolemic mice
title_full_unstemmed A mini-review on quantification of atherosclerosis in hypercholesterolemic mice
title_short A mini-review on quantification of atherosclerosis in hypercholesterolemic mice
title_sort mini-review on quantification of atherosclerosis in hypercholesterolemic mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345319/
https://www.ncbi.nlm.nih.gov/pubmed/35925518
http://dx.doi.org/10.36922/gtm.v1i1.76
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