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Nanocomposite coatings for the prevention of surface contamination by coronavirus

The current Covid-19 pandemic has a profound impact on all aspects of our lives. Aside from contagion by aerosols, the presence of the SARS-CoV-2 is ubiquitous on surfaces that millions of people handle daily. Therefore, controlling this pandemic involves the reduction of potential infections via co...

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Autores principales: Toledo, Esti, Dim, Sharon, Edri, Avishay, Greenshpan, Yariv, Ottolenghi, Aner, Eisner, Nadav, Tzadka, Sivan, Pandey, Ashish, Ben Nun, Haggai, Le Saux, Guillaume, Porgador, Angel, Schvartzman, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345348/
https://www.ncbi.nlm.nih.gov/pubmed/35917302
http://dx.doi.org/10.1371/journal.pone.0272307
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author Toledo, Esti
Dim, Sharon
Edri, Avishay
Greenshpan, Yariv
Ottolenghi, Aner
Eisner, Nadav
Tzadka, Sivan
Pandey, Ashish
Ben Nun, Haggai
Le Saux, Guillaume
Porgador, Angel
Schvartzman, Mark
author_facet Toledo, Esti
Dim, Sharon
Edri, Avishay
Greenshpan, Yariv
Ottolenghi, Aner
Eisner, Nadav
Tzadka, Sivan
Pandey, Ashish
Ben Nun, Haggai
Le Saux, Guillaume
Porgador, Angel
Schvartzman, Mark
author_sort Toledo, Esti
collection PubMed
description The current Covid-19 pandemic has a profound impact on all aspects of our lives. Aside from contagion by aerosols, the presence of the SARS-CoV-2 is ubiquitous on surfaces that millions of people handle daily. Therefore, controlling this pandemic involves the reduction of potential infections via contaminated surfaces. We developed antiviral surfaces by preparing suspensions of copper and cupric oxide nanoparticles in two different polymer matrices, poly(methyl methacrylate) and polyepoxide. For total copper contents as low as 5%, the composite material showed remarkable antiviral properties against the HCoV‐OC43 human coronavirus and against a model lentivirus and proved well-resistant to accelerated aging conditions. Importantly, we showed that the Cu/CuO mixture showed optimal performances. This product can be implemented to produce a simple and inexpensive coating with long-term antiviral properties and will open the way to developing surface coatings against a broad spectrum of pathogens including SARS-CoV-2.
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spelling pubmed-93453482022-08-03 Nanocomposite coatings for the prevention of surface contamination by coronavirus Toledo, Esti Dim, Sharon Edri, Avishay Greenshpan, Yariv Ottolenghi, Aner Eisner, Nadav Tzadka, Sivan Pandey, Ashish Ben Nun, Haggai Le Saux, Guillaume Porgador, Angel Schvartzman, Mark PLoS One Research Article The current Covid-19 pandemic has a profound impact on all aspects of our lives. Aside from contagion by aerosols, the presence of the SARS-CoV-2 is ubiquitous on surfaces that millions of people handle daily. Therefore, controlling this pandemic involves the reduction of potential infections via contaminated surfaces. We developed antiviral surfaces by preparing suspensions of copper and cupric oxide nanoparticles in two different polymer matrices, poly(methyl methacrylate) and polyepoxide. For total copper contents as low as 5%, the composite material showed remarkable antiviral properties against the HCoV‐OC43 human coronavirus and against a model lentivirus and proved well-resistant to accelerated aging conditions. Importantly, we showed that the Cu/CuO mixture showed optimal performances. This product can be implemented to produce a simple and inexpensive coating with long-term antiviral properties and will open the way to developing surface coatings against a broad spectrum of pathogens including SARS-CoV-2. Public Library of Science 2022-08-02 /pmc/articles/PMC9345348/ /pubmed/35917302 http://dx.doi.org/10.1371/journal.pone.0272307 Text en © 2022 Toledo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Toledo, Esti
Dim, Sharon
Edri, Avishay
Greenshpan, Yariv
Ottolenghi, Aner
Eisner, Nadav
Tzadka, Sivan
Pandey, Ashish
Ben Nun, Haggai
Le Saux, Guillaume
Porgador, Angel
Schvartzman, Mark
Nanocomposite coatings for the prevention of surface contamination by coronavirus
title Nanocomposite coatings for the prevention of surface contamination by coronavirus
title_full Nanocomposite coatings for the prevention of surface contamination by coronavirus
title_fullStr Nanocomposite coatings for the prevention of surface contamination by coronavirus
title_full_unstemmed Nanocomposite coatings for the prevention of surface contamination by coronavirus
title_short Nanocomposite coatings for the prevention of surface contamination by coronavirus
title_sort nanocomposite coatings for the prevention of surface contamination by coronavirus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345348/
https://www.ncbi.nlm.nih.gov/pubmed/35917302
http://dx.doi.org/10.1371/journal.pone.0272307
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